Evaluation of EUS-Guided 22 Gauge Core Biopsy Versus Fine-needle Aspiration for Suspected Pancreatic Neoplasms

Inclusion Criteria:

* Age greater than 18 and less than 90 years.
* Presence of a solid (greater than 60%) mass lesion within the pancreas on cross-sectional imaging, without a preceding tissue diagnosis.
* Absence of an uncorrectable coagulopathy as defined by abnormal prothrombin time (PT) or partial thromboplastin time (PTT) that does not correct with the administration of fresh frozen plasma.
* The patient must read and speak english and has signed informed consent document.
* The patient is scheduled for diagnostic endosonography by their referring provider or UVa gastroenterologist.

Exclusion Criteria:

* Age less than 18 or greater than 90 years.
* The patient is unable to read or understand the consent form.
* The patient is currently pregnant.
* The patient has an uncorrectable coagulopathy as defined by a prolonged prothrombin time (PT) or partial thromboplastin time (PTT) which does not improve with administration of fresh frozen plasma.
* The patient has a pancreatic mass lesion which is predominantly cystic (greater than 40%).
* No mass lesion is identified at the time of endosonography.