Clinical trial · Observational
Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic qualities and lack of respiratory depression. Patients sedated with dexmedetomidine could be easily roused, these advances shows dexmedetomidine may be a effective and safe sedative agent. But some studies showed some adversely effects of dexmedetomidine on haemodynamics (such as bradycardia, hypotension), the investigators want to further research the effects of dexmedetomidine on haemodynamics, such as Cardiac Output (CO), Systemic Venous Resistance Index(SVRI), and so on. Propofol is widely used sedative agent in ICU, it also has adversely effects like bradycardia and hypotension, so the investigators want to compare the effect of dexmedetomidine with propofol on haemodynamics after major abdominal surgery. Expect to further research the mechanism of haemodynamics of dexmedetomidine.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abdominal Tumor | — | UNRESOLVED | — |
| Aneurism | — | UNRESOLVED | — |
| Cirrhosis | — | UNRESOLVED | — |
| Intestinal Fistula | — | UNRESOLVED | — |
| Intestinal Obstruction | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| dexmedetomidine | Drug | — | UNRESOLVED |
| propofol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- dexmedetomidine,hemodynamics,injection
- description
- Group 1:when the patient can be roused after major abdominal surgery ，we will inject dexmedetomidine at 1μg/kg in 10 minutes as a loading dose, followed by a continuous infusion at 0.3μg/kg/h for 6 to 24hours.then adjust the infusion dose to maintain the ramsay scale at 3-4 scores.
- interventionNames
- Drug: dexmedetomidine
- label
- propofol,hemodynamics,injection
- description
- Group 2 :when the patient can be roused after major abdominal surgery ，we will inject propofol at 0.5mg/kg as a loading dose, followed by a continuous infusion at 0.5mg/kg.h for 6 to 24hours.then adjust the infusion dose to maintain the ramsay scale at 3-4 scores
- interventionNames
- Drug: propofol
Primary outcomes (1)
- measure
- Cardiac output
- timeFrame
- the study will start when the patient can be roused after major abdominal surgery and will continue for 6 to 24hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Postoperative patients of major abdominal surgery 2. Age ≧ 18 Exclusion Criteria: 1. heart rate ≤ 50 bpm 2. allergy with dexmedetomidine or propofol 3. pregnancy
References
Publications (0)
Data not yet available