Clinical trial · Interventional
Sector Irradiation Versus Whole Brain Irradiation for Brain Metastasis
Sector Irradiation Versus Whole Brain Irradiation After Resection of Singular or Solitary Brain Metastasis - a Prospective Randomized Monocentric Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Microneurosurgical resection of intracerebral metastases leads to prolonged survival and relief of symptoms in selected patients. To minimize the risk of intracranial recurrence whole brain irradiation has been established as standard adjuvant treatment in those patients. Sector irradiation resembles a brain - tissue - sparing method by focusing the irradiation in the area of the tumor bed and a surrounding 1mm security margin. The aim of this study is to investigate whether adjuvant "sector""-irradiation following microsurgical resection is equal to adjuvant whole brain irradiation in terms of local control and superior to in terms of quality of life and neurocognitive deficits in a prospective randomized trial.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastatic Malignant Neoplasm to the Adult Brain | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| sector irradiation | Radiation | — | UNRESOLVED |
| whole brain irradiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- whole brain irradiation
- description
- whole brain irradiation with 40 Gy, with fixation mask, radiation of the entire brain, skull base and meninges
- interventionNames
- Radiation: whole brain irradiation
- type
- EXPERIMENTAL
- label
- sector irradiation
- description
- irradiation of the resection margin plus 5 mm safety margin with 30 Gy in 5 fractions
- interventionNames
- Radiation: sector irradiation
Primary outcomes (1)
- measure
- local tumor control
- timeFrame
- time from date of randomization until the date of first documented progression, assessed up to 36 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Solitary/singular brain metastasis * Karnofsky Performance Index \> 60% * Stable extracranial disease /CUP * Informed consent Exclusion Criteria: * Small cell lung cancer * Squamous cell lung cancer * HER2-negative breast cancer * Deep-seated location (e.g. basal ganglia) * Expected surgery related neurological deficit * Tumor diameter \< 3cm
References
Publications (1)
- DERIVEDKerschbaumer J, Pinggera D, Holzner B, Delazer M, Bodner T, Karner E, Dostal L, Kvitsaridze I, Minasch D, Thome C, Seiz-Rosenhagen M, Nevinny-Stickel M, Freyschlag CF. Sector Irradiation vs. Whole Brain Irradiation After Resection of Singular Brain Metastasis-A Prospective Randomized Monocentric Trial. Front Oncol. 2020 Nov 24;10:591884. doi: 10.3389/fonc.2020.591884. eCollection 2020. PMID 33330076