Clinical trial · Observational
Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer
Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer at Moffitt Cancer Center and Lehigh Valley Hospital
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to find out whether Endoscopic Ultrasound (EUS) can detect early stage pre-cancerous or cancerous changes in the pancreas in patients at high-risk for the development of pancreatic cancer. Endoscopic refers to the use of an instrument called an endoscope - a thin, flexible tube with a tiny video camera and light on the end. Ultrasound refers to an imaging technique that uses sound waves to produce pictures. EUS in this research study is a method of combining endoscopy and ultrasound imaging to obtain high quality images of the pancreas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopic Ultrasound (EUS) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Endoscopic Ultrasound (EUS) Participants
- description
- High-risk for Pancreatic Cancer: Patients with 2 or more relatives with pancreatic cancer and a first degree relationship with at least one of the relatives with pancreatic cancer.
- interventionNames
- Procedure: Endoscopic Ultrasound (EUS)
Primary outcomes (1)
- measure
- Number of Abnormalities Detected by EUS
- timeFrame
- Average of 5 years
- description
- To determine whether targeted screening of these high-risk individuals using Endoscopic Ultrasound (EUS) at regular intervals can detect precancerous pancreas changes or early stage asymptomatic pancreatic cancer.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Patients will be eligible if they have 2 or more relatives with pancreatic cancer and have a first degree relationship with at least one of the relatives with pancreatic cancer * If only 2 family members are affected then both must have had pancreatic cancer and a first-degree relationship with individual screened * If there are more than 2 affected individuals on the same side of the family at least one of the individuals must have a first-degree relationship with the member being screened * Patients at least 40 years old or 10 years younger than the youngest affected individual * Peutz-Jeghers Syndrome (PJS) patients age\>30 * Hereditary pancreatitis patients * Patients with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) * Patients with BRCA2 mutation and at least one first or second degree relative with documented pancreatic cancer * Willingness to undergo (EUS) with possible Fine Needle Aspiration (FNA) * Willingness to undergo surgical evaluation for abnormal EUS/FNA finding * Willingness to undergo radiographic evaluation if screening findings are abnormal Exclusion Criteria: * Medical contraindications to undergoing endoscopy or obstruction of the GI tract that precludes passage of the endoscope * Personal history of pancreatic adenocarcinoma * Previous partial or complete resection of the pancreas for adenocarcinoma * Prior partial or total gastrectomy with Billroth II or Roux-en-Y anastamosis * Previous computed tomography (CT) scan, magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) or EUS of the abdomen in the past 3 years * Coexisting cancer in other organs or acquired immunodeficiency syndrome/human immunodeficiency virus (AIDS/HIV) * Life expectancy less than 5 years * Pregnancy
References
Publications (0)
Data not yet available