Clinical trial · Interventional
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
The Effect of Negative Pressure Therapy on Incisional Surgical Site Infections
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to evaluate if a negative-pressure dressing placed over a surgical incision can reduce the risk of developing a surgical site infection compared to a commonly-used sterile gauze incision dressing. In this study, the negative-pressure dressing will be compared to a standard post-surgical sterile gauze dressing. In this study patients will either receive a negative-pressure dressing or a standard sterile gauze dressing
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
| Perioperative/Postoperative Complications | — | UNRESOLVED | — |
| Primary Peritoneal Cavity Cancer | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| wound care management | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Arm I (SSD)
- description
- Patients receive SSD over their closed laparotomy incision at the conclusion of their surgery.
- interventionNames
- Procedure: wound care management
- type
- EXPERIMENTAL
- label
- Arm II (NPT)
- description
- Patients receive NPT dressing over their closed laparotomy incision at the conclusion of their surgery.
- interventionNames
- Procedure: wound care management
Primary outcomes (1)
- measure
- Rate of incisional surgical site infection (SSI), which includes superficial incisional SSIs and deep incisional SSIs as defined by the Center of Disease Control and Prevention
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Surgical resection for a colorectal, pancreatic, or peritoneal surface malignancy * The scheduled procedure will be performed via midline laparotomy * The planned procedure is a clean-contaminated (class II) case (includes gastric, small bowel, and colorectal resections, as well as bile or pancreatic duct transections) * Ability to understand and the willingness to sign a written informed consent document (either directly or via a legally authorized representative) Exclusion Criteria: * Emergent cases will not be included in the study * Pregnant patients will not be included in the study as pregnancy is a relative contraindication for these types of surgical procedures * Clean (class I), contaminated (class III) and dirty (class IV) procedures will likewise be excluded * Patients on chronic immunosuppressive medications, including steroids, within the past three months * Patients with a history of skin allergy to iodine or adhesive drapes * The planned procedure involves foreign material (such as mesh or subcutaneous drains) being left in the subcutaneous space at the time of surgery (for example, a ventral hernia repair); surgical drains that are placed to drain an intraabdominal space and exit the abdominal wall remote from the incision are allowed in the study
References
Publications (0)
Data not yet available