Clinical trial · Observational
Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens
A Population-based Case-control Study of Lung Cancer in Appalachian Kentucky: The Role of Environmental Carcinogens
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a research study about the relationship between lung cancer and environmental risk factors. The purpose of this study is to try to understand the effects of trace elements such as arsenic and chromium, as well as radon on the development of lung cancer. To do this, the investigators will collect information and environmental and biologic specimens from people who live in Appalachian Kentucky who a) have lung cancer or b) don't have lung cancer and will serve as control subjects. The investigators will create a specimen repository of from these people and their residences to compare differences in many risks factors for cancer. By doing this study, the investigators hope to learn why there are more lung cancers in Kentucky's fifth Congressional District than anywhere else in the nation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Environmental sampling | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- lung cancer cases
- description
- subjects with lung cancer who are greater than 17 years of age and live in Appalachian Kentucky
- interventionNames
- Other: Environmental sampling
- label
- control subjects
- description
- subjects without lung cancer, greater than 17 who reside in Appalachian Kentucky
- interventionNames
- Other: Environmental sampling
Primary outcomes (1)
- measure
- Rate of Moderate to High Arsenic Level in Cases and Controls
- timeFrame
- up to three years
- description
- Conduct a case-control study of lung cancer and matched controls in the 5th Congressional District of Kentucky to compare rates of moderate to high arsenic in lung cancer cases and controls (primary endpoint).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
The following eligibility criteria are required for study entry and participation. Inclusion (Lung cancer cases): * Living persons with histologically or cytologically confirmed primary carcinoma of the lung (International Classification of Diseases-9, 162.2-162.9) between October 17, 2011 and October 16, 2013 * Age greater than 17 * Must be residents of the 5th Congressional District * No prior history of any cancer (other than stage I and II non-melanomatous skin cancer) * Must have a working phone * Ability to participate in an in-person interview * English speaking will be eligible for the study (no proxy respondents will be used) Inclusion (Control cases): * Age greater than 17 * No prior history of any cancer (other than stage I and II non-melanomatous skin cancer) * Must be residents of the 5th Congressional District at the time they are matched to the case. * Must have a working phone * Ability to participate in an in-person interview * English speaking will be eligible for the study (no proxy respondents will be used) Exclusion: * History of any cancers other than those listed above * Non-residents of the 5th congressional district of Kentucky * Age 17 years or less
References
Publications (0)
Data not yet available