Clinical trial · Interventional
Optimal Timing of Physical Activity in Cancer Treatment
Optimal Timing of a Tailored Physical Activity Program During Chemotherapeutic Cancer Treatment to Reduce Long-term Cardiovascular Morbidity
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The number of long-term cancer survivors is growing. As a result, treatment-related morbidity - such as cardiovascular disease, metabolic syndrome, functional decline and fatigue - is impacting quality of life and impairing survival. Metabolic syndrome in the general population is currently treated with lifestyle advice to increase physical activity (PA) and reduce caloric intake. This approach is still underused as standard care for cancer survivors. The aim of this study is investigate whether a tailored PA program that starts early (during curative chemotherapy with cardiovascular toxic potential) is superior in terms of reducing long-term cancer-treatment-related metabolic syndrome and cardiovascular morbidity to a program that starts late (after completion of chemotherapy).
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Risk Factors | — | UNRESOLVED | — |
| Fatigue | — | UNRESOLVED | — |
| Metabolic Syndrome | — | UNRESOLVED | — |
| Vascular Disorders | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| A tailored physical activity program after chemotherapy | Other | — | UNRESOLVED |
| A tailored physical activity program during chemotherapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Physical activity during chemotherapy
- description
- This group will start with a physical activity program 3 months before the end of their chemotherapeutic regimen. After chemotherapy they will continue the PA program for another 3 months.
- interventionNames
- Other: A tailored physical activity program during chemotherapy
- type
- ACTIVE_COMPARATOR
- label
- Physical activity after chemotherapy
- description
- This group will start with a physical activity program after the end of their chemotherapeutic regimen. The physical activity program wil take 6 months to complete.
- interventionNames
- Other: A tailored physical activity program after chemotherapy
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with testicular, early colon, breast cancer or B-NHL with an indication for systemic chemotherapy with a curative intent * Normal blood count at start of systemic treatment * Patients need to have an adequate physical health, which is defined by diastolic blood pressure \>45 mm Hg or \<95 mm Hg; heart frequency in at rest \< 100 per minute; body temperature below 38°C; respiration frequency in rest below 20 per minute * Adequate cardiac function with a LVEF above the lower limit of normal * Written informed consent Exclusion Criteria: * Infections requiring actual antibiotics * Signs of ongoing bleeding or fresh petechiae; unexplained bruises * Critical organ impairment due to their malignancy * Not recovered from earlier surgical intervention * Non adequate control of any symptoms of the malignancy * Inability to travel independently to the rehabilitation centre * Cognitive disorder or emotional instability that might impede the participation in the training program * Recent cardiovascular event
References
Publications (2)
- DERIVEDvan der Schoot GGF, Ormel HL, Westerink NL, Wempe JB, Lefrandt JD, May AM, Vrieling AH, Meijer C, Gietema JA, Walenkamp AME. Physical exercise in patients with testicular cancer treated with bleomycin, etoposide and cisplatin chemotherapy: pulmonary and vascular endothelial function-an exploratory analysis. J Cancer Res Clin Oncol. 2023 Dec;149(19):17467-17478. doi: 10.1007/s00432-023-05469-5. Epub 2023 Oct 27. PMID 37889308
- DERIVEDvan der Schoot GGF, Ormel HL, Westerink NL, May AM, Elias SG, Hummel YM, Lefrandt JD, van der Meer P, van Melle JP, Poppema BJ, Stel JMA, van der Velden AWG, Vrieling AH, Wempe JB, Ten Wolde MG, Nijland M, de Vries EGE, Gietema JA, Walenkamp AME. Optimal Timing of a Physical Exercise Intervention to Improve Cardiorespiratory Fitness: During or After Chemotherapy. JACC CardioOncol. 2022 Oct 18;4(4):491-503. doi: 10.1016/j.jaccao.2022.07.006. eCollection 2022 Nov. PMID 36444224