Clinical trial · Interventional
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor
NCT01642147CI-TRIAL-00011000completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Hyperemia | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Abdominal surgery under general anesthesia | Procedure | — | UNRESOLVED |
| jugular venous bulb catheterization | Procedure | — | UNRESOLVED |
| Radial artery catheterization | Procedure | — | UNRESOLVED |
| Transcranial Doppler (TCD) | Device | — | UNRESOLVED |
| Tumor removal surgery under general anesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Patients undergoing craniotomy
- description
- Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.
- interventionNames
- Device: Transcranial Doppler (TCD)
- Procedure: jugular venous bulb catheterization
- Procedure: Tumor removal surgery under general anesthesia
- Procedure: Radial artery catheterization
- type
- ACTIVE_COMPARATOR
- label
- Patients undergoing abdominal surgery
- description
- Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.
- interventionNames
- Device: Transcranial Doppler (TCD)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesia (ASA) physical status I or II * Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery. Exclusion Criteria: * Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation. * Preoperatively planned delayed tracheal extubation. * Pregnant or nursing women
References
Publications (7)
- BACKGROUNDRasmussen M, Juul N, Christensen SM, Jonsdottir KY, Gyldensted C, Vestergaard-Poulsen P, Cold GE, Ostergaard L. Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors. Anesthesiology. 2010 Jan;112(1):50-6. doi: 10.1097/ALN.0b013e3181c38bd3. PMID 19952725
- BACKGROUNDRandell T, Niskanen M. Management of physiological variables in neuroanaesthesia: maintaining homeostasis during intracranial surgery. Curr Opin Anaesthesiol. 2006 Oct;19(5):492-7. doi: 10.1097/01.aco.0000245273.92163.8e. PMID 16960480
- BACKGROUNDClavier N, Schurando P, Raggueneau JL, Payen DM. Continuous jugular bulb venous oxygen saturation validation and variations during intracranial aneurysm surgery. J Crit Care. 1997 Sep;12(3):112-9. doi: 10.1016/s0883-9441(97)90040-x. PMID 9328850
- BACKGROUNDBruder N, Pellissier D, Grillot P, Gouin F. Cerebral hyperemia during recovery from general anesthesia in neurosurgical patients. Anesth Analg. 2002 Mar;94(3):650-4; table of contents. doi: 10.1097/00000539-200203000-00031. PMID 11867391
- BACKGROUNDRijbroek A, Boellaard R, Vriens EM, Lammertsma AA, Rauwerda JA. Comparison of transcranial Doppler ultrasonography and positron emission tomography using a three-dimensional template of the middle cerebral artery. Neurol Res. 2009 Feb;31(1):52-9. doi: 10.1179/174313208X325191. Epub 2008 Jul 25. PMID 18662500
- BACKGROUNDSorond FA, Hollenberg NK, Panych LP, Fisher ND. Brain blood flow and velocity: correlations between magnetic resonance imaging and transcranial Doppler sonography. J Ultrasound Med. 2010 Jul;29(7):1017-22. doi: 10.7863/jum.2010.29.7.1017. PMID 20587424
- BACKGROUNDMacmillan CS, Andrews PJ. Cerebrovenous oxygen saturation monitoring: practical considerations and clinical relevance. Intensive Care Med. 2000 Aug;26(8):1028-36. doi: 10.1007/s001340051315.