Clinical trial · Interventional
Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recent studies estimated that 15 to 20% of all cancers in humans are associated with viruses. Among oral cancer about 90% are oral squamous cell carcinomas (OSCC). Alcohol and tobacco consumption have been recognized for years as the main risk factors for development of OSCCs. However, 10 to 20% of patients suffering from OSCCs are non-smokers and/ or non-drinkers. Consequently, the hypothesis of another agent responsible has risen. Indeed, several studies have suggested the possibility that a virus could be associated with or be a causal agent of OSCC. The first objective is to detect and characterize the presence of infectious agent (mostly virus) transcripts in pre-malignant or malignant tumours from patients with OSCCs.The secondary objectives are (i) to associate and (ii) if possible define a causality link between these agents and a subset of potentially malignant disorders and/or OSCCs.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukoplakia Oral | — | UNRESOLVED | — |
| Squamous Cell Carcinoma of the Oral Cavity | Oral Cavity Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| contralateral healthy tissue biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- contralateral healthy tissue biopsy
- interventionNames
- Procedure: contralateral healthy tissue biopsy
Primary outcomes (2)
- measure
- Detection and characterization of HPV (human papillomavirus)by using qPCR (quantitative polymerase chain reaction) method.
- timeFrame
- 30 months
- description
- qPCR method
- measure
- Detection of others infectious agents
- timeFrame
- 30 months
- description
- (i) a high -density panviral resequencing microarray (RMA) and (ii) High-Throughput Sequencing (HTS)
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient over 18 years, * For subgroup "potentially malignant disorder : clinical diagnosis of leukoplakia, * For subgroup "OSCC" : histological diagnosis of OSCC, * Patient who never smoked, or light smoker, (≤5 pack-year) or 15 years of cessation, * Patient who never drank, or light drinker (≤ 20 g/day for men and 10g/day for women) or 15 years of cessation, * Informed consent signed. Exclusion Criteria: • Previous treatment of oral cancer,
References
Publications (0)
Data not yet available