Clinical trial · Interventional
Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer
Phase Ⅱ Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer
NCT01635400CI-TRIAL-00007348unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to find out the correlation between uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Small Cell Carcinoma of Lung | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Irinotecan | Drug | Irinotecan | ALIAS |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- UGT1A1 wild type (6/6)
- interventionNames
- Drug: Irinotecan
- type
- OTHER
- label
- UGT1A1 heterozygous genotype (6/7)
- interventionNames
- Drug: Irinotecan
- type
- OTHER
- label
- UGT1A1 homozygous genotype(7/7)
- interventionNames
- Drug: Irinotecan
Primary outcomes (1)
- measure
- Side effect of chemotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of refractory or relapsed small cell lung cancer * Physical examination and routine laboratory tests show no contraindications to chemotherapy Exclusion Criteria: * Pregnant and nursing women * Brain metastasis with symptoms
References
Publications (0)
Data not yet available
No reference posted for this study.