Clinical trial · Interventional
Increasing Uptake of Colorectal Cancer Screening in Ontario
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators hope to determine whether the addition of an FOBT kit and educational materials to a second mailed invitation compared to a second mailed invitation alone increases use of appropriate screening tests (FOBT for average risk or colonoscopy if increased risk) by eligible persons within 6 months of the second mailing in: (1)Non-responders to an initial mailed CRC screening invitation from their family physician and, (2)Those who responded to the initial mailed CRC screening invitation and are due for repeat screening (i.e., "recall" patients). In addition, the investigators will also explore the impact of the investigators intervention in likely under-screened groups such as those living in more remote areas of the province and those with low socio-economic status as well as assessing the cost-effectiveness of this strategy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Disorders | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| FOBT kit | Other | — | UNRESOLVED |
| Mailed invitation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Non-responders
- description
- Non-responders to an initial mailed CRC screening invitation from their family physician. FOBT kit. Mailed invitation.
- interventionNames
- Other: FOBT kit
- Other: Mailed invitation
- type
- OTHER
- label
- Recall patients
- description
- Those who responded to the initial mailed CRC screening invitation and are now due for repeat screening (i.e., "recall" patients). FOBT kit. Mailed invitation.
- interventionNames
- Other: FOBT kit
- Other: Mailed invitation
Primary outcomes (1)
- measure
- Uptake of appropriate CRC screening
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Recipients of a mailed CRC screening invitation through the CCO Invitation Pilot project * No OHIP record of completion of FOBT since initial mailing (Non-responders arm only) * No OHIP of 'CRC Cancer Screening Exclusion' tracking code since initial mailing (Non-responders arm only) * An OHIP record of completion of FOBT 6 months since initial mailing (Recall arm only) * Negative result according to LRT or if not in LRT, no record of interval colonoscopy in CIRT or OHIP (Recall arm only) Exclusion Criteria: * Age greater than 74 years at time of mailing * Interval diagnosis of colorectal cancer * Interval colonoscopy or flexible sigmoidoscopy * Interval departure from Pilot physician's practice * Death * Presently institutionalized * Physician has declined participation in the study * Interval record of repeat FOBT (Recall arm only)
References
Publications (1)
- DERIVEDTinmouth J, Patel J, Austin PC, Baxter NN, Brouwers MC, Earle C, Levitt C, Lu Y, Mackinnon M, Paszat L, Rabeneck L. Increasing participation in colorectal cancer screening: results from a cluster randomized trial of directly mailed gFOBT kits to previous nonresponders. Int J Cancer. 2015 Mar 15;136(6):E697-703. doi: 10.1002/ijc.29191. Epub 2014 Sep 23. PMID 25195923