Clinical trial · Interventional
Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors
NCT01627535CI-TRIAL-00020588completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial studies optical imaging in assessing activity during surgery in patients with brain tumors. New procedures, such as optical spectroscopy, may help doctors maximally remove brain tumors and minimize damage to normal brain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interoperative Optical Imaging and Spectroscopy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Optical Imaging
- description
- Patients undergo i2DOS
- interventionNames
- Other: Interoperative Optical Imaging and Spectroscopy
Primary outcomes (2)
- measure
- Determination of the effectiveness of intraoperative optical imaging technology and optical spectroscopy.
- timeFrame
- Day 1 post surgery
- description
- Optical reflectance images will be analyzed by pixel by-pixel subtraction of a control trial and a stimulation trial. This subtracted image will then be divided by the control image to normalize for differences between subjects and trials. These ratios thus represent proportional changes from baseline.
- measure
- Intraoperative determination of the location of critical brain functions.
- timeFrame
- Day 1 post surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Neurosurgical patient population in the City of Hope brain and spinal tumor neurosurgical programs that have been diagnosed with a brain tumor. * Only lucid patients qualified to consent to neurosurgical procedure will be approached for participation in this study. * We do intend to enroll subjects with potentially terminal brain tumors. Due to the potential benefit of intraoperative mapping, we are not planning to exclude these subjects. * Patients with any type of brain tumor will be eligible for participation. * All subjects must have the ability to understand and the willingness to sign a written informed consent. Exclusion Criteria: * There are no exclusion criteria except for individuals without a brain tumor and the location of the craniotomy. If the exposed area of brain is not compatible with peripheral stimuli or volitional activity the subject cannot be enrolled. * Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.
References
Publications (0)
Data not yet available
No reference posted for this study.