Multiple Antigen-Engineered DC Vaccine for Melanoma

Inclusion Criteria:

* Ability and willing to give consent
* Patients age 18 and older with recurrent, inoperable stage III, IV, M1a, b or c melanoma (any tumor thickness and any number of lymph node involvement, and in-transit metastases, or distant metastases) (AJCC).

Previously treated with any form of therapy (including chemotherapy, radiation therapy, immunotherapy or surgery) for either metastatic, relapsed, or primary melanoma are eligible for this trial, provided the previous treatment was completed \> 30 days prior to enrollment.

* Patients should have at least 2 subcutaneous, intracutaneous, and accessible tumor deposits, lymph node or other site available for biopsy purposes.
* Both men and women may be enrolled. Premenopausal females must have a negative pregnancy test prior to treatment and lactating females will have to discontinue breast feeding to be eligible.
* ECOG Performance Status of 0 or 1.
* No previous evidence of class 3 or greater New York Heart Association cardiac insufficiency or coronary artery disease.
* No previous evidence of opportunistic infection.
* Adequate baseline hematological and organ function as assessed by the following laboratory values within 28 days prior to study entry:

Hemoglobin \>/=9 g/dL Granulocytes \>/=2,000/mm3 Lymphocytes \>/=1000/mm3 Platelets \>100,000/mm3 Serum Creatinine \</=1.5 X the ULN AST, ALT, GGT, CPK, LDH, Alk phos \</=2.5 X the ULN Serum Bilirubin \</=1.5 X ULN In addition to study entry, the above hematological and organ function lab values along with the ECOG PS must be met prior to starting IFNα treatment.

* Subjects must have normal coagulation parameters as measured by PT/PTT,unless the subject is on an anticoagulation therapy.

Exclusion Criteria:

* Females of child-bearing potential (pre-menopausal) must have a negative serum beta-HCG pregnancy test at screening.
* Subjects with acute infection: any acute viral, bacterial, or fungal infection which requires specific therapy. Acute therapy must have been completed more than 14 days prior to study treatment.
* Hep B \& C and HIV-infected patients, due to concerns in the ability to stimulate an effective immune response (determined by historical medical data).
* Subjects with acute medical problems such as ischemic heart or lung disease that may be considered an unacceptable anesthetic or operative risk.
* Subjects with any underlying conditions which would contraindicate therapy with study treatment (or allergies to reagents).
* Subjects with organ allografts.
* Subjects must be free of known brain metastases by contrast-enhanced CT/MRI scans or have successfully-treated brain metastases and be asymptomatic for more than 1 month.
* Patients requiring immunosuppressive therapy for comorbid conditions.
* Concomitant Medication and Treatment: All allowed medications or treatments should be kept to a minimum and recorded. All questions regarding concomitant medications should be referred to the Investigator.
* Long term concurrent medications and/or treatments Not Allowed: Corticosteroids, chemotherapy, cyclosporin A. Short term (approximately 1 week) use of topical, low-dose or inhaled steroids may be allowed at the discretion of the investigator. Injectables not allowed.