Clinical trial · Interventional
Polarized Reflectance Spectroscopy for Oral Lesions
Evaluation of Polarized Reflectance Spectroscopy for Detection of High-risk Oral Lesions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study the investigators are conducting research to determine whether a new optical device using polarization reflectance spectroscopy can help doctors or dentists identify abnormalities in the mouth that require follow-up. To establish this, measurements are needed from a large number of individuals with different abnormalities in their mouth. The investigators believe the proposed approach has potential to improve and enable mass screening for precancerous and early cancers of the oral cavity by improving the predictive value of oral cavity exams, particularly for less experienced practitioners. The information from this study will be compared to results from the pathology report of the tissue taken from your mouth. Hypothesis: 1. Polarized reflectance spectroscopy can distinguish high-risk oral lesion from normal and reactive oral lesions. 2. Polarized reflectance spectroscopy can capture low-grade oral lesions that have characteristics associated with a high risk of progression to cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Polarized Reflectance Spectroscopy System | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Polarized probe measurement.
- description
- All patients belong under this arm as all will be measured by the polarized probe and the data will be compared to the biopsy site's pathology results.
- interventionNames
- Device: Polarized Reflectance Spectroscopy System
Primary outcomes (1)
- measure
- To use the spectroscopic data collected to create a model for normal, dysplastic and cancerous tissue.
- timeFrame
- 2 years
- description
- The goals of the statistical analysis will be to determine an appropriate model for predicting whether the lesion is normal or abnormal (dysplasia or carcinoma) based on spectroscopic characteristics. The investigators will estimate sensitivity and specificity of the predictions made by the model and compare this to sensitivity and specificity of standard white light clinical examination currently used in clinical practice.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * You attend the Dental Department at the British Columbia Cancer Agency * You have an abnormal lesion in the mouth * You fully understand the study and give your informed consent to participate as demonstrated by signing this consent form Exclusion Criteria: * You are under the age of 18 years.
References
Publications (0)
Data not yet available