Clinical trial · Interventional
A Phase 1 Dose Escalation Study of AV-203, an ERBB3 Inhibitory Antibody, in Subjects With Advanced Solid Tumors
A Phase 1 Open-label, Multiple Dose, Dose Escalation Study of Monoclonal Antibody AV-203 Administered in Subjects With Metastatic or Advanced Solid Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a Phase 1, multi-center, open-label, multiple dose, dose escalation study to evaluate the safety, tolerability, dose limiting toxicities (DLTs), maximum tolerated dose (MTD) and/or Recommended Phase 2 Dose (RP2D), pharmacokinetic (PK), pharmacodynamics, and preliminary anti-tumor activity of AV-203, an ERBB3 inhibitory antibody, administered once every 2 weeks via intravenous (IV) infusion in subjects with metastatic or advanced solid tumors. Once the RP2D is determined, patients with tumor types of interest will be evaluated in an expansion cohort at the RP2D for safety and anti-tumor activity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Solid Tumors | Solid Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| AV-203 | Biological | Anti-ErbB3 Monoclonal Antibody AV-203 | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Dose-escalation AV-203 Monotherapy
- description
- dose-escalation of monotherapy AV-203 (an ERBB3 inhibitory antibody) by IV every two weeks
- interventionNames
- Biological: AV-203
Primary outcomes (1)
- measure
- Incidence of AEs, SAEs and Dose-limiting Toxicities (DLTs)
- timeFrame
- Ongoing throughout study. DLTs evaluated for first cycle of therapy. 1 cycle = 28 days
Secondary outcomes (10)
- measure
- Maximum Plasma Concentration (Cmax) of AV-203
- timeFrame
- pre-dose, 5 min, 15 min, 7 hr, 24 hr, 168 hr post-dose
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * ≥ 18 years of age * Histologically and/or cytologically confirmed primary diagnosis * Metastatic or advanced solid tumor, that has recurred or progressed following standard therapies, or for which no standard therapy exists * Must have available tumor tissue or be willing to undergo biopsy prior to enrollment * Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1 * Blood Chemistry and Hematology results within defined limits Exclusion Criteria: * History of severe allergic or anaphylactic reactions or hypersensitivity to recombinant proteins or excipients in the investigational agent * Current central nervous system (CNS) or leptomeningeal metastases, or history of CNS or leptomeningeal metastases. * Significant conduction disturbance, history of a severe arrhythmia, or history of a familial arrhythmia * Significant cardiovascular disease * Significant thromboembolic or vascular disorders within prior 3 months * Any other medical condition or psychiatric condition that, in the opinion of the Investigator, might interfere with the subject's participation in the trial or interfere with the interpretation of trial results * Known history of positive results for hepatitis C, hepatitis B, or human immunodeficiency virus. * For female subjects, pregnancy or lactation.
References
Publications (0)
Data not yet available