Clinical trial · Observational
Social Cognition in Children Treated for a Brain Tumour
Social Cognition in Children Treated for a Brain Tumour: A Prospective Longitudinal Multi-Centre Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is ample evidence that children treated for a brain tumour (BT) often develop deficits in social and emotional functioning. The investigators wish to examine the cause of these deficits, i.e. the underlying neuropsychological deficit(s). The aim is to study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a BT in childhood as compared to a reference group of chronically ill children. If we can identify the specific deficits these patients experience, neuropsychological treatment and guidance can be developed to give patients the most optimal chances to live as normal as possible, to improve their quality of life (QoL) and to prevent them from developing depression and anxiety. Eventually, an intervention programme could be developed based on our results, to improve social, vocational and emotional QoL.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Cystic Fibrosis | — | UNRESOLVED | — |
| Social Behaviour | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Brain Tumour Patients
- description
- Newly diagnosed brain tumour patients aged between 5 and 13 years
- label
- Cystic Fibrosis patients
- description
- Patients diagnosed with Cystic Fibrosis aged between 5 and 13 years
- label
- Healthy control group
- description
- Healthy children aged between 5 and 13 years
Primary outcomes (1)
- measure
- Social cognitive performance
- timeFrame
- baseline and 3 years later
- description
- Change in performance on tests of social cognition from time 1 (diagnosis) to time 2 (3 years later).
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 5-13 years at first assessment (All groups) * Newly diagnosed brain tumour patients that have not yet received adjuvant therapy (BT patients only) * Stable medical condition (BT and CF patients only) Exclusion Criteria: * Diagnosed with a disorder of the autistic spectrum (Autism, Asperger's Syndrome or Pervasive Developmental Disorder not otherwise specified - All groups) that does not seem to be related to the tumour (BT patients only). * History of other brain disease or neurological condition interfering with normal development (All groups). * No native Dutch speaker (All groups) * Severe sensory handicaps and/or behavioural problems interfering with reliable neuropsychological assessment (All groups) * IQ below 70 (All groups) * Poor prognosis and life expectancy less than 1 year (BT patients only)
References
Publications (2)
- BACKGROUNDKok TB, Post WJ, Tucha O, de Bont ES, Kamps WA, Kingma A. Social competence in children with brain disorders: a meta-analytic review. Neuropsychol Rev. 2014 Jun;24(2):219-35. doi: 10.1007/s11065-014-9256-7. Epub 2014 Mar 20. PMID 24648014
- BACKGROUNDKok TB, Koerts J, Lemiere J, Post WJ, de Bont ESJM, Gidding C, Happe F, Jacobs S, Oostrom K, Schieving J, Tucha O, Kingma A. Social competence in newly diagnosed pediatric brain tumor patients. Pediatr Hematol Oncol. 2020 Feb;37(1):41-57. doi: 10.1080/08880018.2019.1682089. Epub 2019 Nov 4. PMID 31682775