Clinical trial · Observational
Do Your Genes Put You at a Higher Risk of Developing Mesothelioma
Consortium for the Sharing of Germ Line DNA and Tissue From Subjects With Mesothelioma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to investigate the possibility that a person's genes put a person at a higher risk of developing mesothelioma. The investigators will examine genes from DNA (genetic material) isolated from blood. This study will also examine the impact of environmental and work exposures and family history of common cancers on the development of mesothelioma. The genetic markers in this study will basically identify how a person's body processes frequently encountered environmental pollutants and will not tell about chromosomes, specific diseases, or other potential health problems.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Mesothelioma | Malignant Mesothelioma | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Mesothelioma
- description
- Individuals who have been diagnosed with mesothelioma
Primary outcomes (1)
- measure
- Creation of a consortium of investigators (6 sites) for collection of blood for germline DNA and demographic information from 1000 mesothelioma subjects.
- timeFrame
- Participants will be seen on one occasion lasting 30-60 min to draw blood and elicit demographic information. It will require up to 2 years to enroll 1000 subjects with mesothelioma from the various sites.
- description
- Demographic variables that will be collected include; date of birth, gender, age at first exposure to asbestos, type of exposure (occupational or bystander), family health history, personal past medical history, smoking history, age at diagnosis, latency, tumor location and cell type.
Secondary outcomes (1)
- measure
- GWAS will be performed on the DNA from the 1000 subjects with mesothelioma and compared with 1000 age and asbestos exposure matched controls free of past personal history and family history of cancer.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects able to provide informed consent who suffer from mesothelioma Exclusion Criteria: * Inability to provide informed consent * Absence of mesothelioma in self
References
Publications (35)
- BACKGROUNDBertazzi PA. Descriptive epidemiology of malignant mesothelioma. Med Lav. 2005 Jul-Aug;96(4):287-303. PMID 16457426
- BACKGROUNDPaul S, Neragi-Miandoab S, Jaklitsch MT. Preoperative assessment and therapeutic options for patients with malignant pleural mesothelioma. Thorac Surg Clin. 2004 Nov;14(4):505-16, ix. doi: 10.1016/j.thorsurg.2004.06.008. PMID 15559057
- BACKGROUNDXu L, Flynn BJ, Ungar S, Pass HI, Linnainmaa K, Mattson K, Gerwin BI. Asbestos induction of extended lifespan in normal human mesothelial cells: interindividual susceptibility and SV40 T antigen. Carcinogenesis. 1999 May;20(5):773-83. doi: 10.1093/carcin/20.5.773. PMID 10334193
- BACKGROUNDBocchetta M, Di Resta I, Powers A, Fresco R, Tosolini A, Testa JR, Pass HI, Rizzo P, Carbone M. Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10214-9. doi: 10.1073/pnas.170207097. PMID 10954737
- BACKGROUNDKamp DW, Weitzman SA. Asbestosis: clinical spectrum and pathogenic mechanisms. Proc Soc Exp Biol Med. 1997 Jan;214(1):12-26. doi: 10.3181/00379727-214-44065. PMID 9012357
- BACKGROUNDSluis-Cremer GK. Asbestos disease at low exposures after long residence times. Ann N Y Acad Sci. 1991 Dec 31;643:182-93. doi: 10.1111/j.1749-6632.1991.tb24461.x. No abstract available. PMID 1809131
- BACKGROUNDNeragi-Miandoab S. Multimodality approach in management of malignant pleural mesothelioma. Eur J Cardiothorac Surg. 2006 Jan;29(1):14-9. doi: 10.1016/j.ejcts.2005.10.008. Epub 2005 Dec 15. PMID 16343925
- BACKGROUNDBerry G, Wagner JC. Effect of age at inoculation of asbestos on occurrence of mesotheliomas in rats. Int J Cancer. 1976 Apr 15;17(4):477-83. doi: 10.1002/ijc.2910170410.