Clinical trial · Interventional
Anesthesia and Cancer Recurrence im Malignant Melanoma
Long-term Outcome After Radical Lymph Node Dissection of Malignant Melanoma. Comparison Between Regional Versus General Anesthesia With Respect to Impact of Perioperative Immunoediting and Validation of New Potential Predictive Biomarkers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Studies in animals and retrospective studies in humans show that regional anesthesia reduces metastatic cancer dissemination. The investigators hypothesize that in patients suffering from malignant melanoma who have to undergo radical inguinal lymph node dissection immune function will be less compromised and long term survival will be superior when spinal anesthesia is compared to general anesthesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Melanoma | Melanoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane | Procedure | — | UNRESOLVED |
| Spinal anesthesia with Bupivacaine hyperbar 0.5 % | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Regional anesthesia
- interventionNames
- Procedure: Spinal anesthesia with Bupivacaine hyperbar 0.5 %
- type
- ACTIVE_COMPARATOR
- label
- General anesthesia
- interventionNames
- Procedure: General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- five years
Secondary outcomes (6)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients scheduled for inguinal lymph node dissection because of malignant melanoma of the lower limb * Signed informed consent Exclusion Criteria: * Age \< 18 years * Female patients who are pregnant or nursing * Multiple organ failure * Contraindications
References
Publications (0)
Data not yet available