Clinical trial · Interventional
Neoadjuvant Pemetrexed, Carboplatin and Bevacizumab in Unresectable, Locally Advanced Lung Adenocarcinoma
A Phase II Study of Neoadjuvant Pemetrexed, Carboplatin and Bevacizumab in Unresectable, Locally Advanced Lung Adenocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The prognosis of patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) is poor. Chemoradiotherapy is the main treatment modality for this disease. The newer drug regimens can be expected to improve survival in this subset of NSCLC patients. Modern targeted therapies have enhanced the outcomes of lung cancer treatment, especially for advanced NSCLC. Among the targeted approaches for the inhibition of angiogenesis is bevacizumab, a monoclonal antibody that represses vascular endothelial growth factor (VEGF). Bevacizumab in combination with platinum-based chemotherapy used as neoadjuvant chemotherapy may change the previous treatment modality. It allows some lung cancer patients to be downstaged to surgery rather than radiotherapy. Thus, survival of these patients may be improved.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neoadjuvant Bevacizumab | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Neoadjuvant Bevacizumab
- description
- Four cycles of neoadjuvant chemotherapy with pemetrexed, carboplatin and bevacizumab.
- interventionNames
- Drug: Neoadjuvant Bevacizumab
Primary outcomes (1)
- measure
- Resectability rate
- timeFrame
- 3 months
Secondary outcomes (3)
- measure
- Number of participants with perioperative complications
- timeFrame
- 4 months
- measure
- Disease-free survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed unresectable, locally advanced (III A (bulky N2), III B) lung adenocarcinoma * No previous chemotherapy, radiotherapy, surgery or biological therapy for lung cancer * Adequate organ and bone marrow function Exclusion Criteria: * Prior chemotherapy or radiation therapy for NSCLC * Prior treatment with bevacizumab or other agents specifically targeting vascular endothelial growth factor (VEGF) * Patients with known hypersensitivity to other recombinant human antibodies * History of stroke or transient ischemic attack (TIA). * History of myocardial infarction or unstable angina within the past 12 months. * Other serious illness or medical condition including unstable cardiac disease requiring treatment, history of significant neurologic or psychiatric disorders (including psychotic disorders, dementia, or seizures), symptomatic diverticulitis, or active uncontrolled infection. * Women who are pregnant or breast-feeding
References
Publications (0)
Data not yet available