Clinical trial · Interventional
Use of Harmonic in Breast Surgery
Harmonic Scalpel vs. Electrocautery Dissection in Modified Radical Mastectomy: A Randomized Controlled Trial
NCT01587248CI-TRIAL-00006814HMRMcompletedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To compare harmonic scalpel with electrocautery for outcomes i.e. estimated blood loss (EBL), operating time, drain Volume and drain Days, seroma formation, surgical site infection and postoperative pain in adult females undergoing MRM at a tertiary care hospital. We hypothesized that harmonic yields better outcome than electrocautery dissection.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Modified Radical Mastectomy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| electrocautery | Procedure | — | UNRESOLVED |
| Harmonic | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Electrocautery
- description
- Raising of the flaps with electrocautery
- interventionNames
- Procedure: electrocautery
- type
- EXPERIMENTAL
- label
- Harmonic
- description
- Dissection with harmonic scalpel in modified radical mastectomy
- interventionNames
- Device: Harmonic
Primary outcomes (1)
- measure
- Duration of drains (days)
- timeFrame
- 30 days
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 16 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adult females with biopsy proven breast cancer underwent MRM Exclusion Criteria: * Simultaneous procedure (Reconstruction, Sentinel lymph node biopsy)
References
Publications (1)
- DERIVEDKhan S, Khan S, Chawla T, Murtaza G. Harmonic scalpel versus electrocautery dissection in modified radical mastectomy: a randomized controlled trial. Ann Surg Oncol. 2014 Mar;21(3):808-14. doi: 10.1245/s10434-013-3369-8. PMID 24232511