Clinical trial · Observational
Urinary Protein/Creatinine Ratio in a Single Urine Sample Versus 24-hour Proteinuria in Patients With Multiple Myeloma
Correlation Between the Urinary Protein/Creatinine Ratio in a Single Urine Sample Versus 24-hour Proteinuria in Patients With Multiple Myeloma.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The measurement of 24-hour proteinuria allows an assessment of treatment response in patients with multiple myeloma. But it is difficult and restrictive to make. This study was therefore designed to investigate the correlation between the ratio of proteinuria / creatinine on samples, easier to obtain, and the 24-hour proteinuria in assessing response to this treatment .
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| urinary excretion of FLC immunoglobulin | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- first phase
- description
- This first phase aims to study the variations in urinary excretion of FLC immunoglobulin during the day and night to determine the appropriate time of day for collection of urine. 20 patients hospitalized.
- interventionNames
- Biological: urinary excretion of FLC immunoglobulin
- label
- Second phase
- description
- Determination of creatinine in 24 hours by measuring the creatinine of 24 hours 3 days in a row. This value will check the quality of urine collection for 24 hours during the study. 30 patients hospitalized.
- interventionNames
- Biological: urinary excretion of FLC immunoglobulin
Primary outcomes (1)
- measure
- change in urinary protein/creatinine ratio
- timeFrame
- Change from baseline in urinary protein/creatinine ratio at 8 AM, 12 AM, 4 PM
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * For the first part of the study : * adult patient * giving a free, informed and written consent * patient having a follow-up in the service for multiple myeloma, whatever the age of diagnosis, the isotype of monoclonal component, stage and disease activity * patient hospitalized in the service whatever the reason for hospitalization (related or not with multiple myeloma) * proteinuria ≥ 500 mg/24h * percentage of albuminuria \< 50% on urinary protein electrophoresis * presence of immunoglobulin FLC in immunofixation of urine proteins * For the second part of the study : * adult patient * giving a free, informed and written consent * patient having a follow-up in the service for multiple myeloma, whatever the age of diagnosis, the isotype of monoclonal component * requiring the initiation of treatment with chemotherapy * proteinuria ≥ 500 mg/24h * percentage of albuminuria \< 50% on urinary protein electrophoresis * presence of immunoglobulin FLC in urine proteins immunofixation Exclusion Criteria: * minor patient * proteinuria \< 500 mg/24h * predominantly glomerular proteinuria with ≥ 50% albumin on urinary protein electrophoresis * absence of immunoglobulin FLC in urine proteins immunofixation * progressive urinary infection * patient with a glomerular nephropathy * macroscopic hematuria * patient unable to perform a urinary collection for 24 hours * patient unable to give a consent * pregnant or lactating woman
References
Publications (0)
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