Clinical trial · Interventional
Narrow-Band Imaging Versus Standard White Light for the Detection of Serrated Lesions in the Proximal Colon
Randomized Controlled Trial Comparing the Use of Narrow-Band Imaging Versus Standard White Light for the Detection of Serrated Lesions in the Proximal Colon
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a study to determine if using Narrow-Band Imaging of the colon, rather than the usual white light on the colon, will improve the detection of a type of polyp called serrated. The polyps are called serrated because of their appearance under the microscope after they have been removed. They tend to be located up high in the colon, far away from the rectum. They have been definitely shown to be a type of precancerous polyp and it is possible that using Narrow-Band Imaging will make it easier to see them, as they can be quite difficult to see with standard white light.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Inspection with Narrow-Band Imaging(NBI) | Procedure | — | UNRESOLVED |
| Standard White Light | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Narrow-Band Imaging (NBI)
- description
- Inspection with Narrow-Band Imaging(NBI) versus inspection with standard white light(usual care)
- interventionNames
- Procedure: Inspection with Narrow-Band Imaging(NBI)
- type
- ACTIVE_COMPARATOR
- label
- Standard White Light
- description
- Inspection with Standard White Light versus Narrow-Band Imaging(NBI)
- interventionNames
- Procedure: Inspection with Narrow-Band Imaging(NBI)
- Procedure: Standard White Light
Primary outcomes (2)
- measure
- Total Number of Serrated Lesions Proximal to the Sigmoid Colon
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Age 50-85 * Intact colon and rectum * American Society of Anesthesiology risk class 1, 2 or 3 Exclusion Criteria: * No prior surgical resection of colon or rectum
References
Publications (1)
- DERIVEDRex DK, Clodfelter R, Rahmani F, Fatima H, James-Stevenson TN, Tang JC, Kim HN, McHenry L, Kahi CJ, Rogers NA, Helper DJ, Sagi SV, Kessler WR, Wo JM, Fischer M, Kwo PY. Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial. Gastrointest Endosc. 2016 Jan;83(1):166-71. doi: 10.1016/j.gie.2015.03.1915. Epub 2015 May 5. PMID 25952085