Clinical trial · Observational
Matrilysin Expression in Different Stages of Colorectal Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology. Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with metastatic disease even though it is expressed in most tumor states. Our purpose is to analyse MMP-7 in bowel and lymph nodes of different tumor stages and to evaluate its expression as a potential biomarker of cancer disease in patients surgically treated for benign and malignant colorectal tumors. Tumoral tissue, lymph nodes and serum samples from recruited Patients plus serum samples from healthy volunteers are analysed for matrilysin expression by histology, immunohistochemistry, ELISA and Western blotting. If Matrilysin increases with increasing dysplasia and cancer disease stage in tumor tissue as well as in the regional lymph nodes it might be used as a complement in investigating suspected locally advanced cancer.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer Stage 0 | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Cancer Stage I | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Cancer Stage II | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Cancer Stage III | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Cancer Stage IV | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| colonic or colorectal resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- healthy volunteers
- description
- healthy subjects not affected by benign or malignant colonic disease
- interventionNames
- Procedure: colonic or colorectal resection
- label
- benign colonic tumor patients
- description
- patients affected by benign colonic tumor such as adenoma
- interventionNames
- Procedure: colonic or colorectal resection
- label
- cancer patient I-II stage
- description
- Patients affected by colonic cancer in I-II stage
- interventionNames
- Procedure: colonic or colorectal resection
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 83 Years
Show eligibility criteria text
Inclusion Criteria: * benign colonic neoplasm not suitable for endoscopic treatment, * malignant colonic neoplasm with indication to primary surgical treatment Exclusion Criteria: * neo-adjuvant radiotherapy, * chemo-radiotherapy, * language problems and withdrawal of consent
References
Publications (1)
- BACKGROUNDMori M, Barnard GF, Mimori K, Ueo H, Akiyoshi T, Sugimachi K. Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas. Cancer. 1995 Mar 15;75(6 Suppl):1516-9. doi: 10.1002/1097-0142(19950315)75:6+3.0.co;2-7. PMID 7889484