Pharmacokinetics of LCZ696 in Subjects With Mild and Moderate Renal Impairment Compared to Healthy Subjects With Normal Renal Function

Inclusion Criteria:

1. Male, and female subjects of non-child bearing potential,
2. Subjects were to weigh at least 50 kg to participate in the study,
3. and body mass index \< 40 kg/m2
4. Subjects were able to communicate well with the investigator, to understand and comply with the requirements of the study;
5. Subjects were able to understand and sign the written informed consent;

For renal insufficient subjects:

1. stable renal disease without evidence of renal progressive

   * mild renal function: calculated CrCl of 50-≤80 mL/min
   * moderate renal function: calculated CrCl of 30-\<50 mL/min
2. Vital signs:

   * oral body temperature between 35.0-37.8 °C
   * systolic blood pressure, 95-180 mm Hg
   * diastolic blood pressure, 60-110 mm Hg
   * pulse rate, 54-95 bpm

For healthy subjects only

1. A serum creatinine with a calculated CrCl of \>80 mL/min
2. Vital signs:

   * oral body temperature between 35.0-37.2 °C
   * systolic blood pressure, 95-140 mm Hg
   * diastolic blood pressure, 60-100 mm Hg
   * pulse rate, 45-90 bpm

Exclusion Criteria:

1. Current use of ACE inhibitors, valsartan, and drugs that were known as CYP2C9 substrates, potassium-sparing diuretics;
2. Smokers;
3. History of renal transplant at any time in the past and on immunosuppressant therapy;
4. Dialysis patients;
5. Medical history of clinically significant ECG abnormalities or a family history of a prolonged QT-interval syndrome;
6. Any surgical or medical condition which may significantly alter the absorption, distribution, metabolism or excretion of any drug substance; Other protocol defined inclusion/exclusion criteria may apply