Clinical trial · Interventional
A Study of Ganetespib in Subjects With ALK-Positive Non-Small-Cell Lung Cancer (NSCLC)
A Single Arm, Phase 2 Study of Ganetespib in Subjects With Advanced Non-Small-Cell Lung Cancer With Anaplastic Lymphoma Kinase Gene Rearrangement (ALK-Positive NSCLC)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase 2 study of subjects with ALK positive, advanced NSCLC who have failed up to 3 prior therapies. The study will take place globally at multiple study centers. Subjects will be enrolled to receive ganetespib one time per week for three weeks followed by a rest week; and will repeat this schedule until the cancer gets worse or the subject is unable to tolerate ganetespib. The primary goal of the study is to determine how ganetespib is tolerated and how active it is in ALK positive NSCLC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ganetespib | Drug | Ganetespib | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Ganetespib
- description
- Ganetespib IV infusion once per week for three consecutive weeks followed by a 1 week dose-free interval
- interventionNames
- Drug: Ganetespib
Primary outcomes (1)
- measure
- Objective response rate
- timeFrame
- 1 year
Secondary outcomes (5)
- measure
- Duration of Response
- timeFrame
- 1 year
- measure
- Disease Control Rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Males or females aged 18 years or older * Pathological confirmation of advanced NSCLC * Evidence of a translocation or an inversion event involving the ALK gene locus * ECOG Performance Status 0 or 1 Exclusion Criteria: * Prior therapy with ALK-targeted agents * Prior treatment with Hsp90 inhibitor * Known EGFR activating mutation * Presence of active or untreated central nervous system (CNS) metastases
References
Publications (0)
Data not yet available