Clinical trial · Interventional
Intravitreal Injections of Melphalan for Retinoblastoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Sufficient findings to draw conclusions
Summary
Brief summary (as posted)
Retinoblastoma treatment has become more and more focused in the last years. New treatments developed by Dr. Kaneko from Japan in 1995 are now being tested in clinical trials. Intra-arterial chemotherapy with Melphalan has shown success in some patients but with limited response when there is marked vitreal seeding. For these cases Intravitreal injections of Melphalan have been successful in Japan. In this study the same chemotherapy (melphalan) will be administered intravitreally (directly through the eye wall) and the response (short and long term) will be monitored.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Retinoblastoma | Retinoblastoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| IVit Melphalan | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- IVit Treatment group
- description
- Intravitreal injections of Melphalan
- interventionNames
- Drug: IVit Melphalan
Primary outcomes (1)
- measure
- treatment response
- timeFrame
- 1 year
- description
- short term response to treatment and long term complications
Secondary outcomes (1)
- measure
- complications
- timeFrame
- 1 year
- description
- short and long term complications
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Retinoblastoma that has not responded to chemotherapy * Retinoblastoma that has vitreal seeding Exclusion Criteria: * previous failure of IVit Melphalan
References
Publications (0)
Data not yet available