Clinical trial · Interventional
Changing the Paradigm of In-Hospital Cardiopulmonary Resuscitation
Changing the Paradigm of In-Hospital Cardiopulmonary Resuscitation With Informed Assent: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Outcomes after in-hospital cardiopulmonary resuscitation (CPR) are very poor, particularly in patients with oxygen dependent chronic obstructive pulmonary disease (COPD) or metastatic cancer. Recent work found that in-hospital CPR is being performed more often before death with unchanging survival and that fewer CPR survivors are being discharged home, thus suggesting that CPR is increasingly performed without benefit and that the burden of this ineffective treatment is increasing. Unlike other medical procedures, CPR has become the default provided to all patients even those with tremendously poor outcomes. It is time to change the paradigm of CPR. Through comparing an innovative "informed assent" approach toward in-hospital CPR (informing patients that their underlying chronic illness makes outcomes of CPR so poor that CPR is not performed while allowing them to disagree) versus usual care in a group of chronically ill patients with reduced life expectancy, the investigators aspire to demonstrate that CPR delivery can be reduced. And in addition that DNR status increases, while preserving patient quality of life and decreasing the burden of this ineffective treatment to both patients and families. If effective, this informed assent intervention has the potential to revolutionize how the investigators discuss CPR with the investigators chronically ill patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Malignancy | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Oxygen Dependent COPD | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Informational Brochure | Behavioral | — | UNRESOLVED |
| Informed Assent | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Informational brochure
- description
- Patients receive an informational brochure
- interventionNames
- Behavioral: Informational Brochure
- type
- EXPERIMENTAL
- label
- Intervention
- description
- Patients receive physician-directed informed assent intervention regarding CPR and informational brochure.
- interventionNames
- Behavioral: Informed Assent
Primary outcomes (1)
- measure
- Cardiopulmonary Resuscitation Preference
- timeFrame
- Within couple of hours before the intervention and immediately (up to 2 days) after the intervention
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years or older * Oxygen dependent COPD or Advanced Malignancy * Life expectancy of less than two years Exclusion Criteria: * Subjects who have already firmly decided to undergo CPR * Subjects enrolled in a hospice program * Subjects unable to speak English * Subjects incapable of making their own decisions at the time of enrollment * Subjects cared for by the study investigator
References
Publications (0)
Data not yet available