Clinical trial · Interventional
Cryopreservation of Ovarian Tissue
Cryopreservation of Ovarian Tissue for Potential In Vitro Maturation or Autologous Transplantation
NCT01558544CI-TRIAL-00098708recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a genetically related child.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Fertility Preservation | — | UNRESOLVED | — |
| Risk of Premature Ovarian Failure | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| surgery to remove ovaries or high dose chemotherapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Use of high dose chemotherapy
- description
- Use of chemotherapy without removal of the disease ovary.
- interventionNames
- Procedure: surgery to remove ovaries or high dose chemotherapy
Primary outcomes (1)
- measure
- CRYOPRESERVATION OF OVARIAN TISSUE FOR POTENTIAL IN VITRO MATURATION OR AUTOLOGOUS TRANSPLANTATION
- timeFrame
- 6 months to a year post surgery, hormone testing will be performed to test ovarian function.
- description
- Ovarian tissue cryopreservation Survival of tissue undergoing cryopreservation, thawing and maturation of immature eggs.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Females 0-45 years of age who are premenopausal * Treatment plan that will likely result in premature menopause or premature ovarian failure * This includes patients receiving: * Cancer treatment with abdominal pelvic irradiation and/or high dose chemotherapy * Surgery that requires removal of ovaries for medical condition or disease, e.g. Prophylactic oophorectomy in BRCA patients * Patient is unable or unwilling to pursue fertility preservation by freezing oocytes or embryos. * Previous treatment for cancer is acceptable if patient still has ovarian function * Patient is medically stable enough to undergo surgery (cleared for anesthesia) Exclusion Criteria: * Patients not meeting the above criteria * Patients who have not received medical clearance from their physicians to undergo surgery * Patients already experiencing menopause.
References
Publications (0)
Data not yet available
No reference posted for this study.