Clinical trial · Interventional
Pre-habilitation to Improve Outcomes in Patients Undergoing Liver Resection for Cancer
Improving Outcomes in Patients With Hepatobiliary Cancers With a Nutritional and Physical Conditioning Pre-habilitation Program
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
1. To determine whether a combined nutritional support program and exercise-based prehabilitation is superior to nutritional support alone in increasing functional recovery and reducing post-operative morbidity after surgery for HPB malignancy. 2. To understand which measures of immediate surgical recovery are sensitive to prehabilitation interventions and predict change in later outcome measures.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Biliary Tract Neoplasm | — | UNRESOLVED | — |
| Colorectal Neoplasm | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Liver Neoplasm | Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| prehab exercise | Other | — | UNRESOLVED |
| Whey protein and dietary supplements | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Nutritional supplementation and prehab
- description
- The first group (pre-hab) will receive both nutritional supplementation and a prehabilitation program.
- interventionNames
- Dietary Supplement: Whey protein and dietary supplements
- type
- ACTIVE_COMPARATOR
- label
- Prehab exercise
- interventionNames
- Other: prehab exercise
Primary outcomes (1)
- measure
- Change in six minute walk test
- timeFrame
- 8 weeks pre-op and 1 week pre-op
- description
- The primary outcome is patient-relevant, functional walking capacity as measured by the six-minute walk test (6MWT). The 6MWT evaluates the ability of an individual to maintain a moderate level of physical activity over a time period reflective of the activities of daily living
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects eligible to enter the prehabilitation program will include those aged 18 and above and referred electively for resection of malignancies. Exclusion Criteria: * Excluded will be persons with American Society of Anesthesiologists (ASA) health status class 4-5 or co-morbid medical, physical and mental conditions (e.g. dementia, disabling orthopedic and neuromuscular disease, psychosis), cardiac abnormalities, severe end-organ disease such as cardiac failure, COPD, and hepatic failure (ALT and AST \>50% over the normal range), and sepsis), morbid obesity (BMI \>40), anemia (hematocrit \< 30 %) and other conditions interfering with the ability to perform exercise at home or to complete the testing procedures. * Patients will be excluded if they have poor English or French comprehension.
References
Publications (0)
Data not yet available