Clinical trial · Interventional
The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing One-lung Ventilation for Lung Surgery
NCT01540201CI-TRIAL-00013234completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pulmonary gas exchange disturbance is a common anesthetic problem during one-lung ventilation (OLV) for thoracic surgery. The inverse-ratio ventilation (IRV), which prolongs the inspiratory time greater than expiratory time, can be applied for adult respiratory distress syndrome. The effect of IRV is to improve gas-exchange status by increasing mean airway pressure and alveolar recruitment. We tried to evaluate the effect of IRV during OLV with lung protective strategy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gas Exchange | — | UNRESOLVED | — |
| Inverse-ratio Ventilation | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| One Lung Ventilation | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional I:E ratio | Other | — | UNRESOLVED |
| I:E = 1:1 ratio | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- 1:2 group
- description
- conventional I:E ratio group, inspiratory time : expiratory time = 1:1
- interventionNames
- Other: Conventional I:E ratio
- type
- EXPERIMENTAL
- label
- 1:1 group
- description
- inspiratory time : expiratory time = 1:1
- interventionNames
- Other: I:E = 1:1 ratio
Primary outcomes (5)
- measure
- arterial CO2 partial pressure
- timeFrame
- 10 minutes after induction of general anesthesia
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing elective lung lobectomy surgery. * the duration of one-lung ventilation is more than one hour. * subjects with more than twenty years old. Exclusion Criteria: * subjects with past history of pneumothorax, asthma * Age under 20, more than 70 years. * Patients with ischemic heart disease, valvular heart disease * patients with hemodynamic unstability
References
Publications (0)
Data not yet available
No reference posted for this study.