Clinical trial · Interventional
Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture
Comparing Injectable Collagenase (CI) and Percutaneous Needle Fasciotomy (PNF) for Dupuytren's Contracture (DC) Affecting Proximal Interphalangeal Joints (PIP). A Randomised Controlled Trial
NCT01538017CI-TRIAL-00024139completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Comparing injectable collagenase and percutaneous needle fasciotomy for Dupuytren's contracture affecting proximal interphalangeal joints. An open label, medico-independent randomized controlled trial.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dupuytrens Contracture | Palmar Fibromatosis | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Percutaneous needle fasciotomy | Procedure | — | UNRESOLVED |
| Xiapex | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Collagenase injection
- description
- Injection of collagenase obtained from Clostridium Histolyticum in contracture string
- interventionNames
- Drug: Xiapex
- type
- ACTIVE_COMPARATOR
- label
- Percutaneous needle fasciotomy
- description
- PNF ad modum Lermusiaux and Debeyre
- interventionNames
- Procedure: Percutaneous needle fasciotomy
Primary outcomes (1)
- measure
- Clinical improvement
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * DC affecting PIP joint with Passive Extension Deficit (PED) more than 20 degrees * Clearly defined strings Exclusion Criteria: * Allergies to used medication * International Normalised Ratio more than 2.0 * Pregnancy and breastfeeding * Previous treatment for DC in affected finger * Former inclusion in the study with another string * Activity in disease at time of study * PED more than 20 degrees for Metacarpophalangeal or Distal Interphalangeal joint in affected digit
References
Publications (0)
Data not yet available
No reference posted for this study.