Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

INCLUSION CRITERIA:

* Survivors of non-metastatic breast, prostate, or colorectal cancer, or stage I/II non-small cell lung cancer
* Age ≥ 18
* Smoked 100 tobacco cigarettes over lifetime at time of first interview, have smoked 10 or more cigarettes per day on most days over the past month
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1 (Karnofsky ≥ 70%)
* Ability to understand and the willingness to sign a written informed consent document
* Agrees to adhere to the study protocol and attend the required clinic visits
* Negative serum pregnancy test within 10 days prior to registration in women with child-bearing potential; women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation
* Women who are currently breast-feeding are not eligible for this study

Exclusion Criteria:

* Use of chewing tobacco, pipe tobacco, snuff, or any other non-cigarette tobacco product is not allowed
* No patients with clinically significant uncontrolled medical conditions (e.g., unstable angina, myocardial infarction, transient ischemic attack \[TIA\], or cerebral vascular accident \[CVA\]) within past 3 months
* Creatinine ≥ 2 times upper limit of normal (ULN) in last six months
* Serum glutamic oxaloacetic transaminase (SGOT)/serum glutamic pyruvate transaminase (SGPT) ≥ 3 times ULN in last six months
* Current uncontrolled hypertension ≥ 160/90 mm Hg
* Excessive alcohol abuse defined as more than 5 drinks per day for men and 4 drinks per day for women
* Major medical or psychiatric illness which, in the opinion of the investigator, would prevent completion of treatment or would interfere with follow-up
* History of allergic reactions attributed to memantine

PRIOR CONCURRENT THERAPY:

* Six months post definitive treatment (except for ongoing hormonal or targeted therapies)
* Patients currently must not be taking Nicotine Replacement Therapy (NRT) and agree to not start NRT for the duration of the study
* Patients currently taking antidepressant or antianxiety medications must have been on a stable dose for 4 weeks prior to registration
* Patients currently receiving the following medications are not eligible: anticonvulsant agents (e.g., phenytoin, carbamazepine, gabapentin, etc.); antiparkinsonian agents (e.g., Levo Dopa, ropinirole); neuroleptic agents (e.g., risperidone, quetiapine); carbonic anhydrase inhibitors (e.g., Diamox® and Sequels®)
* Memantine should not be combined with other N-methyl d-aspartate (NMDA) antagonists (amantadine, ketamine, and dextromethorphan)
* Participants may not be receiving any other investigational agents
* No current use of illegal drugs or use of prescription medications for non-medical reasons