Clinical trial · Interventional
Rectal Cancer: Local Staging, Re-staging and Assessment of Lymph Nodes Using Pet-Ct, CT-Perfusion and 3T MRI
Rectal Cancer: Local Staging, Re-staging and Assessment of Lymph Node Metastases Using PET-CT, CT-Perfusion and 3T MRI: A Prospective Feasibility Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the accuracy of Positron emission tomography, Computed Tomography perfusion and 3 Tesla MRI in the radiological down-staging of rectal cancer following neoadjuvant chemoradiation. The restaging result obtained by these imaging studies will be compared to standard imaging studies and the histopathology of the surgical specimen. We hypothesize that these 3 imaging modalities will detect lymph node metastases pretreatment better than standard pretreatment scans and will better determine the degree of response of the primary rectal tumor to preoperative chemoradiation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ct and mri scans | Radiation | — | UNRESOLVED |
| ct, mri and pet scan | Radiation | — | UNRESOLVED |
| ct, mri and pet scans | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- imaging with ct, mri and pet scans
- description
- ct,mri and pet scans pre and post radiation
- interventionNames
- Radiation: ct and mri scans
- Radiation: ct, mri and pet scan
- Radiation: ct, mri and pet scans
Primary outcomes (1)
- measure
- efficacy of PET, CT-perfusion and MRI to stage patients with rectal cancer
- timeFrame
- 3 years
- description
- The patient will undergo imaging studies with PET, CT-perfusion and MRI before and after standard preoperative chemoradiation and these imaging studies will be compared with standard imaging and with the final pathology specimen in order to determine the accuracy of these 3 studies in detecting lymph node metastases and response of the primary tumour to treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Rectal cancer, stage T2, T3, T4 Exclusion Criteria: * Rectal cancer, stage T1 or metastatic * Non-rectal primary cancer invading the rectum * Mucinous histology * Patient is initially, or becomes a non-surgical candidate during the course of the study * Hip prosthesis (affects PET-CT image processing) * Allergy to CT contrast or patients with impaired renal function, defined as estimated glomerular filtrate rate (eGFR)\< 30 ml/min * Prior radiotherapy to the region of the study that would result in overlap of radiation fields * Contraindications to MRI * Pregnancy
References
Publications (0)
Data not yet available