Clinical trial · Interventional
Prehabilitation in Liver Surgery
Feasibility Study of Preoperative Exercise Intervention in the Resection of Colorectal Liver Metastasis.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Each year in the UK around 1500 patients undergo surgery for bowel cancer that has spread to the liver. This is major surgery that offers a chance of cure, but can be associated with complications. Fitter patients are less likely to have serious complications. We are interested in finding out whether a short exercise program can improve patient fitness before surgery and whether this can reduce surgical complications. We plan to measure the fitness of patients who are going to have liver surgery. We will then give them an exercise programme for 4 weeks, after which we will assess their fitness again. We are also interested in whether fitter people have better Liver function. To assess this we will take a small sample of liver tissue during the operation for laboratory analysis of its function. Hypothesis 1. A short period of exercise can significantly improve fitness prior to liver surgery 2. Greater Fitness is associated with better liver function.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Liver Metastasis | — | UNRESOLVED | — |
| Exercise Intervention | — | UNRESOLVED | — |
| Liver Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Exercise Intervention
- description
- 4 week personalised exercise program on a static bicycle.
- interventionNames
- Behavioral: Exercise Intervention
- type
- NO_INTERVENTION
- label
- Control Arm
- description
- Patients having standard preoperative preparation and advice.
Primary outcomes (1)
- measure
- Anaerobic threshold prior to liver resection
- timeFrame
- 4 weeks
- description
- This is a measure of cardiopulmonary fitness as detected by a cardiopulmonary exercise test.
Secondary outcomes (8)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Planned resection of colorectal liver metastasis * Able to perform cycle based exercise program * Age over 18 Exclusion Criteria: * Unable to consent * Unable to perform cycle based exercise program * Age under 18
References
Publications (1)
- DERIVEDDunne DF, Jack S, Jones RP, Jones L, Lythgoe DT, Malik HZ, Poston GJ, Palmer DH, Fenwick SW. Randomized clinical trial of prehabilitation before planned liver resection. Br J Surg. 2016 Apr;103(5):504-12. doi: 10.1002/bjs.10096. Epub 2016 Feb 11. PMID 26864728