Clinical trial · Observational
Persistent Pain After Breast Cancer Treatment (PPBCT) - Risk Factors and Pathophysiological Mechanisms
NCT01523132CI-TRIAL-00021643completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study is a prospective cohort study following breast cancer patients from before surgery to one year after. The aims of the study are to determine risk factors that predispose to the development of persistent pain.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Lymphedema | — | UNRESOLVED | — |
| Neuropathic Pain | — | UNRESOLVED | — |
| Neuropathy | — | UNRESOLVED | — |
| Persistent Pain | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Breast cancer patients
- description
- Female breast cancer patients without metastasis and locally advanced disease
Primary outcomes (1)
- measure
- Risk factors predisposing for persistent pain after breast cancer treatment
- timeFrame
- 12 months postoperative
- description
- Pre-, intra- and postoperative risk factors predisposing for persistent pain
Secondary outcomes (8)
- measure
- Prevalence of persistent pain after breast cancer treatment
- timeFrame
- 12 months postoperative
- measure
- Prevalence of sensory disturbances after breast cancer treatment
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with breast cancer * 18 years or older Exclusion Criteria: * unable to give written consent * unable to understand Danish * Previous cosmetic surgery in the breast * Previous surgery in ipsilateral breast * Bilateral cancer * Concomitant corrective surgery on contralateral side * Pregnant * Other disease or injury in the nervous system * Psychiatric disease * Alcohol or drug abuse
References
Publications (5)
- BACKGROUNDAndersen KG, Kehlet H. Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain. 2011 Jul;12(7):725-46. doi: 10.1016/j.jpain.2010.12.005. Epub 2011 Mar 24. PMID 21435953
- RESULTAndersen KG, Duriaud HM, Jensen HE, Kroman N, Kehlet H. Predictive factors for the development of persistent pain after breast cancer surgery. Pain. 2015 Dec;156(12):2413-2422. doi: 10.1097/j.pain.0000000000000298. PMID 26176893
- RESULTAndersen KG, Kehlet H, Aasvang EK. Test-retest agreement and reliability of quantitative sensory testing 1 year after breast cancer surgery. Clin J Pain. 2015 May;31(5):393-403. doi: 10.1097/AJP.0000000000000136. PMID 25084072
- RESULTAndersen KG, Duriaud HM, Aasvang EK, Kehlet H. Association between sensory dysfunction and pain 1 week after breast cancer surgery: a psychophysical study. Acta Anaesthesiol Scand. 2016 Feb;60(2):259-69. doi: 10.1111/aas.12641. Epub 2015 Oct 8. PMID 26446738
- RESULTAndersen KG, Aasvang EK, Kroman N, Kehlet H. Intercostobrachial nerve handling and pain after axillary lymph node dissection for breast cancer. Acta Anaesthesiol Scand. 2014 Nov;58(10):1240-8. doi: 10.1111/aas.12393. PMID 25307709