Clinical trial · Interventional
Detection Rate of Liver Metastases With Contrast Enhanced Intraoperative Ultrasound Compared to Regular Imaging
Value of Contrast Enhanced Intraoperative Ultrasound Compared to Preoperative CEUS, CT and MRT in the Treatment of Colorectal Liver Metastases.
NCT01522209CI-TRIAL-00016626CEIOUS-LivercompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study compares the established imaging techniques (CT, MRT, Contrast Ultrasound) with the new method of intraoperative contrast enhanced ultrasound to compare all methods for their rate of detection of colorectal liver metastasis.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer Liver Metastasis | — | UNRESOLVED | — |
| Contrast Enhances Intraoperative Ultrasound | — | UNRESOLVED | — |
| Imaging for Liver Cancer | — | UNRESOLVED | — |
| Imaging for Liver Metastasis | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Contrast Enhanced Ultrasound | Device | — | UNRESOLVED |
| CT Scan (standard) | Radiation | — | UNRESOLVED |
| Liver Surgery | Procedure | — | UNRESOLVED |
| Primovist MRI (3 Tesla) | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Detection of Liver Metastasis during Operation
- timeFrame
- During Operation
- description
- Intraoperative Rate of Detection of Liver Metastasis compared to preoperative Imaging Analysis
Secondary outcomes (3)
- measure
- Comparison of Detection Rate for Liver Metastases of all imaging modalities
- timeFrame
- 1 Week after Operation
- measure
- Comparison of Sensitivity of all imaging modalities
- timeFrame
- one Year
- measure
- Comparison of Specicivity of all imaging modalities
- timeFrame
- one year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Informed Consent Age \> 18 years All Patients presenting with Colorectal Liver Metastasis indicated for Liver Surgery in the study period Exclusion Criteria: * No Informed Consent Possible Pregnancy Patients with hereditary diseases of the metabolic system Liver Cirrhosis CHILD B and C Renal Insufficiency defined as Kreatinin \>2,5 mg/dl PAtients enrolled in other studies
References
Publications (24)
- BACKGROUNDLupinacci R, Penna C, Nordlinger B. Hepatectomy for resectable colorectal cancer metastases--indicators of prognosis, definition of resectability, techniques and outcomes. Surg Oncol Clin N Am. 2007 Jul;16(3):493-506, vii-viii. doi: 10.1016/j.soc.2007.04.014. PMID 17606190
- BACKGROUNDNordlinger B, Van Cutsem E, Rougier P, Kohne CH, Ychou M, Sobrero A, Adam R, Arvidsson D, Carrato A, Georgoulias V, Giuliante F, Glimelius B, Golling M, Gruenberger T, Tabernero J, Wasan H, Poston G; European Colorectal Metastases Treatment Group. Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group. Eur J Cancer. 2007 Sep;43(14):2037-45. doi: 10.1016/j.ejca.2007.07.017. Epub 2007 Sep 4. PMID 17766104
- BACKGROUNDOldhafer KJ, Hogemann D, Stamm G, Raab R, Peitgen HO, Galanski M. [3-dimensional (3-D) visualization of the liver for planning extensive liver resections]. Chirurg. 1999 Mar;70(3):233-8. doi: 10.1007/s001040050636. German. PMID 10230533
- BACKGROUNDLang H, Radtke A, Hindennach M, Schroeder T, Fruhauf NR, Malago M, Bourquain H, Peitgen HO, Oldhafer KJ, Broelsch CE. Impact of virtual tumor resection and computer-assisted risk analysis on operation planning and intraoperative strategy in major hepatic resection. Arch Surg. 2005 Jul;140(7):629-38; discussion 638. doi: 10.1001/archsurg.140.7.629. PMID 16027326
- BACKGROUNDOng KO, Leen E. Radiological staging of colorectal liver metastases. Surg Oncol. 2007 Jul;16(1):7-14. doi: 10.1016/j.suronc.2007.04.001. Epub 2007 May 11. PMID 17499498
- BACKGROUNDCervone A, Sardi A, Conaway GL. Intraoperative ultrasound (IOUS) is essential in the management of metastatic colorectal liver lesions. Am Surg. 2000 Jul;66(7):611-5. PMID 10917467
- Nakano H, Ishida Y, Hatakeyama T, Sakuraba K, Hayashi M, Sakurai O, Hataya K. Contrast-enhanced intraoperative ultrasonography equipped with late Kupffer-phase image obtained by sonazoid in patients with colorectal liver metastases. World J Gastroenterol. 2008 May 28;14(20):3207-11. doi: 10.3748/wjg.14.3207.