Clinical trial · Interventional
Predictive Clinical and Biological Parameters in Breast Cancer
Research of Predictive Clinical and Biological Parameters in Breast Cancer
NCT01521676CI-TRIAL-00108988BC-BIOterminatedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): strategical decision
Summary
Brief summary (as posted)
Research of predictive clinical and biological factors in breast cancer : genomic, proteomic, mutation
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| molecular alteration | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- breast cancer
- description
- blood and tumor sample
- interventionNames
- Genetic: molecular alteration
Primary outcomes (1)
- measure
- molecular alteration in breast cancer
- timeFrame
- average of 4 weeks after diagnosis
- description
- gene expression level
Secondary outcomes (1)
- measure
- relation between molecular alteration and clinical and histological characteristics
- timeFrame
- up to 3 years
- description
- hazard ratio between molecular alteration and clinical and histological characteristics
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * breast cancer * age \> 18 * signed informed consent Exclusion Criteria: * emergency
References
Publications (5)
- RESULTFattori S, Le Roy A, Houacine J, Robert L, Abes R, Gorvel L, Granjeaud S, Rouviere MS, Ben Amara A, Boucherit N, Tarpin C, Pakradouni J, Charafe-Jauffret E, Houvenaeghel G, Lambaudie E, Bertucci F, Rochigneux P, Goncalves A, Foussat A, Chretien AS, Olive D. CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer. Cancer Res. 2023 Sep 15;83(18):3026-3044. doi: 10.1158/0008-5472.CAN-23-0613. PMID 37379438
- RESULTFattori S, Gorvel L, Granjeaud S, Rochigneux P, Rouviere MS, Ben Amara A, Boucherit N, Paul M, Dauplat MM, Thomassin-Piana J, Paciencia-Gros M, Avenin M, Pakradouni J, Barrou J, Charafe-Jauffret E, Houvenaeghel G, Lambaudie E, Bertucci F, Goncalves A, Tarpin C, Nunes JA, Devillier R, Chretien AS, Olive D. Quantification of Immune Variables from Liquid Biopsy in Breast Cancer Patients Links Vdelta2+ gammadelta T Cell Alterations with Lymph Node Invasion. Cancers (Basel). 2021 Jan 25;13(3):441. doi: 10.3390/cancers13030441. PMID 33503843
- RESULTGuerin M, Eyraud R, Tsvetkov P, Finetti P, Giraudo A, Tarpin C, Hassin A, Bechlian D, Mamessier E, Pakradouni J, Boher JM, Goncalves A, Devred F, Bertucci F. The plasma nanoDSF denaturation profiles predict the presence of breast cancer. J Transl Med. 2025 Dec 5;24(1):197. doi: 10.1186/s12967-025-07499-8. PMID 41350712
- RESULTGuerin M, Goncalves A, Toiron Y, Baudelet E, Pophillat M, Granjeaud S, Fourquet P, Jacot W, Tarpin C, Sabatier R, Agavnian E, Finetti P, Adelaide J, Birnbaum D, Ginestier C, Charafe-Jauffret E, Viens P, Bertucci F, Borg JP, Camoin L. Development of parallel reaction monitoring (PRM)-based quantitative proteomics applied to HER2-Positive breast cancer. Oncotarget. 2018 Sep 18;9(73):33762-33777. doi: 10.18632/oncotarget.26031. eCollection 2018 Sep 18. PMID 30333908
- RESULTGoncalves A, Bertucci F, Guille A, Garnier S, Adelaide J, Carbuccia N, Cabaud O, Finetti P, Brunelle S, Piana G, Tomassin-Piana J, Paciencia M, Lambaudie E, Popovici C, Sabatier R, Tarpin C, Provansal M, Extra JM, Eisinger F, Sobol H, Viens P, Lopez M, Ginestier C, Charafe-Jauffret E, Chaffanet M, Birnbaum D. Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study. Oncotarget. 2016 Nov 29;7(48):79428-79441. doi: 10.18632/oncotarget.12714.