Clinical trial · Observational
A Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary Single Photon Emission Tomography (SPECT)
A Pilot Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary SPECT
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radiation-induced liver disease (RILD) is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. Previous studies have shown that both the volume of liver irradiated and the dose of radiation delivered are prominent factors for development of RILD. While use of a population-based normal tissue complication probability model allows investigators to limit the risk of RILD to a clinically acceptable level, a test that permits investigators to determine an individual's risk of RILD during the course of treatment may allow for individualized treatment modifications, either to prevent toxicity or increase efficacy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Liver Irradiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Liver Irradiation
- description
- patients already scheduled to undergo liver irradiation
- interventionNames
- Radiation: Liver Irradiation
Primary outcomes (1)
- measure
- Changes in hepatobiliary single photon emission tomography (SPECT) after radiation therapy
- timeFrame
- 6 months
- description
- Changes in SPECT, which reflect hepatocyte function, will be correlated with specific regions of radiation dose to determine a relationship between dose and radiation-induced damage.
Secondary outcomes (1)
- measure
- measuring values between regional radiation dose and local hepatic function as measured by hepatobiliary SPECT, in normal liver parenchyma
- timeFrame
- 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * cancer patients undergoing radiation of the Liver * women and men who agree to avoid pregnancy * life expectancy of at least 6 months Exclusion Criteria: * pregnant women * breatsfeeding women * prisoners
References
Publications (0)
Data not yet available