Clinical trial · Interventional
Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
Prospective Randomized Study of Laparoscopic Versus Open Liver Resection for Colorectal Metastases
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study is to compare outcomes of laparoscopic versus open liver resection for colorectal metastases in a prospective and randomized study. The study will include all non-anatomic liver resections in our institution. The primary end point is that the use of laparoscopic technique significantly can reduce the frequency of complications to liver resection. Secondary end points are 5-year survival, immediate surgical outcomes, quality of life and degree of impairment of the immune system.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Secondary Malignant Neoplasm of Liver | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic liver resection | Procedure | — | UNRESOLVED |
| Open liver resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Open liver resection
- description
- Patients will be operated with open liver resection
- interventionNames
- Procedure: Open liver resection
- type
- ACTIVE_COMPARATOR
- label
- Laparoscopic liver resection
- description
- Patients will be operated with laparoscopic liver resection
- interventionNames
- Procedure: Laparoscopic liver resection
Primary outcomes (1)
- measure
- 30 Days Perioperative Morbidity
- timeFrame
- Within 30 days after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients eligible for radical liver resection without formal liver resection or without assistance of radiofrequency ablation Exclusion Criteria: * Inability to give written informed concent * Patients with tumors that can't be resected without reconstruction of vessels or bile ducts * Patients with tumors that can't be resected without 1)formal liver resection 2)combination with radiofrequency ablation * Patients with extrahepatic metastasis except resectable metastasis in lungs and adrenals * Pre- and peroperative diagnosis of non radically treatable disease
References
Publications (4)
- DERIVEDDrejian S, Akhavi MS, Grzyb K, Kazaryan A, Fretland AA, Edwin B, Aghayan D. Histopathologic growth patterns as prognostic factor for survival in patients with colorectal liver metastases. Radiol Oncol. 2026 Feb 6;60(1):114-123. doi: 10.2478/raon-2026-0002. eCollection 2026 Mar 1. PMID 41686533
- DERIVEDAghayan DL, Kazaryan AM, Dagenborg VJ, Rosok BI, Fagerland MW, Waaler Bjornelv GM, Kristiansen R, Flatmark K, Fretland AA, Edwin B; OSLO-COMET Survival Study Collaborators. Long-Term Oncologic Outcomes After Laparoscopic Versus Open Resection for Colorectal Liver Metastases : A Randomized Trial. Ann Intern Med. 2021 Feb;174(2):175-182. doi: 10.7326/M20-4011. Epub 2020 Nov 17. PMID 33197213
- DERIVEDFretland AA, Dagenborg VJ, Waaler Bjornelv GM, Aghayan DL, Kazaryan AM, Barkhatov L, Kristiansen R, Fagerland MW, Edwin B, Andersen MH. Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases. Br J Surg. 2019 Sep;106(10):1372-1380. doi: 10.1002/bjs.11227. Epub 2019 Jul 19. PMID 31322735
- DERIVEDFretland AA, Kazaryan AM, Bjornbeth BA, Flatmark K, Andersen MH, Tonnessen TI, Bjornelv GM, Fagerland MW, Kristiansen R, Oyri K, Edwin B. Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet Study): study protocol for a randomized controlled trial. Trials. 2015 Mar 4;16:73. doi: 10.1186/s13063-015-0577-5. PMID 25872027