Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer

Inclusion Criteria:

* Cytologic or histological diagnosis of non-small cell lung cancer
* Patients with disease progression after systemic chemotherapy with two-drug combination regimens that includes a platinum agent or patients with EGFR mutation status who have not been treated
* Patients are diagnosed with multiple brain metastases for the first time in 4 weeks
* Diagnosis of brain metastases is made based on Magnetic resonance imaging (MRI).
* Doctors consider the patient will benefit from WBRT
* No prior brain radiotherapy
* ECOG performance status 0-2
* age:18-75 years
* Neutrophil count ≥1.5×10 to the 9th power/L and platelets≥100×10 to the 9th power/L. hemoglobin ≥90 g/L
* Hepatic: total bilirubin less than or equal to 1.5 times upper limit of normal (ULN) Alanine transaminase (ALT) and aspartate transaminase (AST) less than or equal to 2.5 times ULN (or less than or equal to 5 times ULN in case of known liver involvement)
* Renal: Serum Creatinine less than or equal to 1.5 times upper limit of normal (ULN)
* Patients with measurable brain metastases according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria
* Patients must sign an informed consent indicating that they are aware of the investigational nature of the study

Exclusion Criteria:

* Prior brain radiation therapy
* Solitary brain metastasis according to Magnetic resonance imaging (MRI)
* Mort than 3 extracranial organs have metastatic lesions
* Prior invasive malignancy (skin basal cell cancer, carcinoma in situ of cervix are permissible).
* pregnant or breast feeding women