Clinical trial · Interventional
Helicobacter Pylori Eradication After Endoscopic Resection of Gastric Tumors
Effect of Helicobacter Pylori Eradication on the New Tumor Development After Endoscopic Resection of Gastric Tumors
NCT01510730CI-TRIAL-00006470completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether Helicobacter pylori eradication could reduce the new tumor development after endoscopic resection of gastric tumor.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endoscopic Resection | — | UNRESOLVED | — |
| Gastric Tumor | Gastric Neoplasm | ALIAS | 0.90 |
| Helicobacter Pylori | — | UNRESOLVED | — |
| Metachronous Neoplasms | Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| eradication treatment of Helicobacter pylori infection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- control group
- description
- no treatment for Helicobacter pylori infection
- type
- ACTIVE_COMPARATOR
- label
- treatment group
- description
- treatment group receive eradication treatment for helicobacter pylori infection
- interventionNames
- Drug: eradication treatment of Helicobacter pylori infection
Primary outcomes (1)
- measure
- Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of gastric tumor.
- timeFrame
- we set the time frame as at least three years.
- description
- Primary outcome is the incidence of new cancer development after endoscopic resection of gastric tumors between eradication and control groups. Previous reports showed the incidence of new cancer between two groups differs at least 3years.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * H pylori infected patients with gastric low-grade dysplasia, high-grade dysplasia, and early gastric cancer * Gastric tumor is completely removed through endoscopic resection. Exclusion Criteria: * Patients underwent gastrectomy before enrollment * patients underwent endoscopic resection before enrollment * Previous history of eradication for H. pylori * Pregnancy * Aged \<20 yr old or aged \>75 yr old * Patients underwent additional gastrectomy due to incomplete endoscopic resection
References
Publications (2)
- DERIVEDChoi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC. Effects of Helicobacter pylori eradication for metachronous gastric cancer prevention: a randomized controlled trial. Gastrointest Endosc. 2018 Sep;88(3):475-485.e2. doi: 10.1016/j.gie.2018.05.009. Epub 2018 May 22. PMID 29800546
- DERIVEDChoi J, Kim SG, Yoon H, Im JP, Kim JS, Kim WH, Jung HC. Eradication of Helicobacter pylori after endoscopic resection of gastric tumors does not reduce incidence of metachronous gastric carcinoma. Clin Gastroenterol Hepatol. 2014 May;12(5):793-800.e1. doi: 10.1016/j.cgh.2013.09.057. Epub 2013 Oct 5. PMID 24100112