Pharmacokinetics in Subjects With Renal Impairment

Inclusion Criteria:

\- Body mass index (BMI): ≥ 18 kg/m² and ≤ 35 kg/m²

For subjects with normal renal function:

* Vital signs (pulse rate and blood pressure) within the normal range or showing no clinically relevant deviation
* Estimated creatinine clearance according to the MDRD equation of ≥ 90 mL/min at Screening

For subjects with impaired renal function:

* Laboratory parameters should be within acceptable range for subjects with renal impairment,
* Vital signs: Pulse rate within the normal range of 45-100 beats/minute in supine position after 5 minutes of rest. Blood pressure diastolic below 100 mmHg, and systolic below 160 mmHg for Groups 1-3 and below 180 mmHg for Group 4a and 4b, in supine position after 5 minutes of rest
* Calculated creatinine clearance according to the MDRD equation of \< 90 mL/min at Screening and the possibility of stratification to one of the Groups.

Exclusion Criteria:

* History of malignant disease within the last 5 years or acute malignant disease
* Medical history of wound healing problems and/or any current open wounds
* Current or history of bleeding disorders and/or history of thromboembolic events (considering family history as well); thrombolytics or oral or parenteral anticoagulants within 30 days prior to Day 1
* Electrocardiogram recording (12-lead ECG) with signs of clinically relevant pathology as judged by the Investigator

For subjects with impaired renal function:

* Chronic heart failure non stabilized (New York Heart Association \[NYHA\] class III and IV)
* Acute renal failure of any etiology (including viral, toxic, or drug induced)
* Requiring dialysis
* History of renal transplantation
* Uncontrolled diabetes mellitus as judged by the Investigator