Clinical trial · Interventional
A Feasibility Study Using Four-Dimensional CT Imaging for Primary Lung Cancer
A Feasibility Study Using Four-Dimensional CT Imaging to Evaluate Lung Strain in Patients Treated With External Beam Radiation Therapy for Primary Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Eligible lung cancer patients: Undergo pre-treatment 4D-CT study for treatment planning External Beam Radiation: standard fractionation (2Gy per day) or stereotactic body radiation therapy Evaluation: Repeat 4D-CT study at 3 months and 6 months post-treatment Primary objectives: To assess pre-treatment global and focal lung strain and correlate with changes post-treatment
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 4D-CT pre-treatment scan | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Study Arm
- description
- Single Arm
- interventionNames
- Radiation: 4D-CT pre-treatment scan
Primary outcomes (1)
- measure
- validate lung strain modeling using 4D-CT in a lung cancer patient population to correlate pre-treatment strain with post-treatment changes.
- timeFrame
- Pre-treatment (baseline) up to 6 months post-treatment
- description
- The study will be a prospective, non-randomized, single center, trial to assess and quantify lung strain using 4D-CT treatment planning scans.
Secondary outcomes (3)
- measure
- correlate 4D-CT based lung strain modeling with standard lung function studies including pulmonary function tests and ventilation-perfusion scans.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age \>/= 18 years 2. ECOG performance status 0-1 3. Pathologic or clinical diagnosis of lung malignancy 4. Patients must have a reproducible tidal volume sufficient for 4D-CT imaging 5. Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential. 6. Women of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth control 7. Patients must provide study specific informed consent prior to study entry. Exclusion Criteria: 1. Patients with severe pulmonary dysfunction with non-reproducible tidal volumes sufficient for 4D-CT imaging. 2. Pregnant women or lactating women
References
Publications (0)
Data not yet available