Clinical trial · Observational

Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma

Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis

NCT01493830CI-TRIAL-00022942completedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Neuroblastoma	Neuroblastoma	ONTOLOGY_EXACT	0.90

Interventions

Interventions (8)

Intervention	Type	Mapped drug	Match
fluorescence in situ hybridization	Genetic	—	UNRESOLVED
gene expression analysis	Genetic	—	UNRESOLVED
immunohistochemistry staining method	Other	—	UNRESOLVED
laboratory biomarker analysis	Other	—	UNRESOLVED
microarray analysis	Genetic	—	UNRESOLVED
microscopy	Other	—	UNRESOLVED
mutation analysis	Genetic	—	UNRESOLVED
protein analysis	Genetic	—	UNRESOLVED

Design

Arms and outcomes

Arms (0)

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Primary outcomes (3)

measure
Expression of UBE4B, hrs, and members of the ubiquitination protein complex
measure
Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors
measure
1p36 deletion status and its association with UBE4B

Eligibility

Eligibility (as posted)

Sex: All
Maximum age: 120 Years

Show eligibility criteria text

DISEASE CHARACTERISTICS:

* Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

References

Publications (0)

Data not yet available

No reference posted for this study.