Clinical trial · Interventional
Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management.
A Comparison Between Continuous Infusion vs. Patient Controlled Intraabdominal Injection of Local Anesthetics for Treatment of Postoperative Pain After Abdominal Hysterectomy. A Randomized, Double-blind Study.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Local anesthetics (LA) are increasingly used for postoperative pain management. Speicifically, several studies have found benefit of LA injected intra-abdominally following abdominal hysterectomy. However, it remains unclear whether the pain relief seen is due to local anesthetic mechanisms within the abdominal cavity or through systemic absorption. The aim of this study is to assess whether lidocaine administered intravenously has similar analgesic efficacy as the same dose administered intra-abdominally in patients undergoing abdominal hysterectomy. All patients would have rescue analgesia using the patient controlled analgesia (PCA) pump with morphine in order to achieve adequate pain management during 24 h.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Persistent Post-menpausal Bleeding | — | UNRESOLVED | — |
| Uterine Cancer | Malignant Uterine Neoplasm | ALIAS | 0.90 |
| Uterine Myoma | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intra-abdominal Lidocaine | Drug | — | UNRESOLVED |
| Intravenous Lidocaine | Drug | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Intravenous Lidocaine
- description
- Intravenous lidocaine would be administered as an infusion for pain management both intra- and post-operatively.
- interventionNames
- Drug: Intravenous Lidocaine
- type
- ACTIVE_COMPARATOR
- label
- Intra-abdominal Lidocaine
- description
- Lidocaine would be administered intermittently, once each hour intra-abdominally for postoperative pain management.
- interventionNames
- Drug: Intra-abdominal Lidocaine
- type
- PLACEBO_COMPARATOR
- label
- Normal saline
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * ASA 1-2 * 30 - 75 yrs * Informed consent * 50 - 100 kg Exclusion Criteria: * Allergy to LA * Chronic pain * Major liver/kidney insufficiency * AV Block 1-2 Participation in another clinical trial
References
Publications (0)
Data not yet available