Clinical trial · Interventional
The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation
The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation in the Patients Undergoing Neurosurgery
NCT01489137CI-TRIAL-00007844completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| AVM | — | UNRESOLVED | — |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| ICH | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| remifentanil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- neurosurgery with fixation
- interventionNames
- Drug: remifentanil
Primary outcomes (2)
- measure
- mean arterial blood pressure
- timeFrame
- peri-fixation periord
- description
- mean arterial blood pressure will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.
- measure
- heart rate
- timeFrame
- peri-fixation periord
- description
- heart rate will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing neurosurgery that require head fixation with mayfield head holder * patients who agree to our study Exclusion Criteria: * patients who don't agree to our study * BMI\<16.0 or BMI\>30 * cardiovascular disease, pulmonary disease, renal disease * alcoholic abuser or drug abuser * patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system * any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period
References
Publications (1)
- DERIVEDLee JM, Bahk JH, Lim YJ, Lee J, Lim L. The EC90 of remifentanil for blunting cardiovascular responses to head fixation for neurosurgery under total intravenous anesthesia with propofol and remifentanil based on bispectral index monitoring: estimation with the biased coin up-and-down sequential method. BMC Anesthesiol. 2017 Oct 10;17(1):136. doi: 10.1186/s12871-017-0426-z. PMID 29017455