Pharmacokinetic (PK) Study of OxyNorm Injections in Chinese Patient

Inclusion Criteria:

* Patients with tumor pain / postoperative pain, or subjects with pain caused by other diseases;
* Patients aged \>30 to ≤ 60 years;
* Body weight ≥ 45kg, and BMI range ≥19, \<24;
* Karnofsky score ≥ 70;
* Expected survival is above 3 months;
* The results of liver function and kidney tests must meet the following criteria:ALT、AST is within the upper limit of normal value ranges by a factor 2, and TB、BUN、Cr is within the upper limit of normal value ranges by a factor 1.25;
* The electrocardiogram examination results are normal;
* Patients must have given a written informed consent prior to this trial, and have the capability to complete every required test.

Exclusion Criteria:

* Have hypersensitivity history to any opioids;
* Have known hypersensitivity to any of compositions of the study drugs;
* Patients who are likely to have paralytic ileus or acute abdomen or to perform an operation on abdominal region；
* Patients with respiratory depression, cor pulmonary, or chronic bronchial asthma;
* Patient unable to stop taking monoamine oxidase inhibitor during this trial period or time lapses less than 2 weeks since drug withdrawal;
* Patients with hypercarbia;
* Patients with biliary tract diseases, pancreatitis, prostatic hypertrophy, or corticoadrenal insufficiency;
* Patients with alcoholism or drug abuse history;
* Positive ant-HIV or syphilis antibody test result;
* Urine screening before study is positive for the opioids, barbiturates, amphetamines, cocaine metabolites, methadone, diazepam and cannabinoids;
* Donated 400 mL or more of blood or blood products within 3 months prior to the start of the study, or donated 200 mL or more of blood or blood products within one month prior to the start of the study.
* Subjects who participated in a clinical research study within two months of study entry.
* Patients who are currently taking opioids.