IPO-NEC Trial:Study on the Efficacy and Safety Using Sequential IP Therapy and Oct Lar in the Treatment of Advanced GI NEC

Inclusion Criteria:

* Written Informed consent
* Male or female patients \>=18 years old
* Histologically or cytologically confirmed poorly differentiated neuroendocrine carcinoma originating from the GI tract. The grade of the disease is grade 2 or grade 3
* No previous treatment is allowed including chemotherapy, radiotherapy,immunotherapy or others. In case the patient received adjuvant therapy after surgery, enrollment is allowed if the adjuvant therapy doesn't contain cisplatin or irinotican and at the same time, the last day of chemotherapy is ≥180 days before screening.
* Target lesion more than 1cm in diameter by enhanced CT or MRI 21 days before enrollment
* The laboratory parameter meets the following criteria 7 days before enrollment
* Hemoglobin ≥90g/L
* Absolute neutrophil count≥1.5×10\^9/L, platelets 100×10\^9/L；
* ALT and AST≤2.5 ULN(in case of the patients with liver metastasis,ALT and AST≤5.0 ULN)
* ALP ≤2.5 ULN (in case of the patients with liver metastasis,≤5.0 ULN)
* Total Serum bilirubin ≤1.5 ULN
* Serum creatinine ≤1.0 ULN
* KPS ≥70
* Estimated survival ≥90 days
* Women of childbearing potential must have a negative serum or urine pregnancy test within 7 days of enrollment and must be willing to use adequate methods of contraception during the study and for 30 days after last study durg administration.

Exclusion Criteria:

* Known sensitivity to 5-HT3 antagonist and hypersensitivity to the other treatment agents including irinotecan, cisplatin and octreotide lar
* Any participation in trials simultaneously or 4 weeks before screening.
* Undergone major surgery ≤ 4 weeks prior to starting study drug or who have not recovered from side effects of such surgery.
* Uncontrolled severe diarrhea
* Unconrolled active infection (fever ≥38 degrees due to infection)
* severe hepatopathy including active hepatitis and hepatic cirrhosis, renal dysfunction, severe pulmonary diseases including interstitial pneumonia, pulmonary fibrosis and severe pulmonary emphysema, uncontrolled diabetes, hypertension and other chronic systematic diseases.
* Chronic treatment with steroids.(In case of the patients with short-term use of steroids, the enrollment is permitted if the administration is stopped 2 weeks before screening.)
* confirmed or suspected CNS metastasis
* the history of peripheral nervous system impairment, obvious mental disorder or CNS impairment
* clinically significant heart disease, including congestive heart failure, symptomatic coronal heart disease, arrythmia uncontrolled by medication and acute myocardial infarction or cardiac insufficiency within 6 months before screening
* pregnant women or women in lactation period
* Fertile male or women of child-bearing potential refuse to take highly effective methods of birth control
* Incidence of other second primary malignant tumors, except for cured basal cell carcinoma and cervical carcinoma in situ.
* patients of legal incapacity or who have the potential of influence the whole trial due to medical or ethic reasons.
* Other patients who are not eligible to the trial under investigators' discretion