Clinical trial · Interventional
Interventions to Improve Colon Cancer Screening in Poor Rural Iowa Counties
Randomized Clinical Trial to Improve Colon Cancer Screening in Poor Rural Iowa Counties
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of the study is to conduct a randomized clinical trial to test several office-based strategies for improving colon cancer screening among individuals who are regular patients at 16 family practice physician offices in the state of Iowa. These offices are members of the Iowa Research Network (IRENE), a rural practice-based research network. The interventions to be tested are increasing in intensity from the usual care provided in the office, to physician chart reminders, mailed educational materials to patients, a fecal immunochemical test with postage-paid return envelope, and a telephone call designed to determine attitudes and barriers to screening, and to motivate subjects to get screened. Our main research questions are: 1)do attitudes toward CRC screening change after providing educational materials about CRC screening? 2)do mailed educational materials and a FIT, with or without a telephone reminder, result in increased rates of CRC testing with the FIT?
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| chart reminder, educational mat'ls, FIT | Behavioral | — | UNRESOLVED |
| CR,ed mat'ls, FIT, phone call | Behavioral | — | UNRESOLVED |
| Physician chart reminder | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- physician chart reminder
- description
- either a paper or an electronic reminder placed on the subject's medical record to remind the physician to screen for colorectal cancer
- interventionNames
- Behavioral: Physician chart reminder
- type
- ACTIVE_COMPARATOR
- label
- chart reminder, educational mat'ls, FIT
- description
- physician chart reminder plus mailed educational materials, including the Centers for Disease Control CRC Screen for Life, the ACS DVD on CRC screening, a fecal immunochemical test with postage-paid return mailer, a magnet reminding individuals to get screened, and a CRC screening preference sheet where subjects could indicate their preferred CRC test
- interventionNames
- Behavioral: Physician chart reminder
- Behavioral: chart reminder, educational mat'ls, FIT
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 52 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * patients not up-to-date with CRC screening guidelines based on their responses to baseline survey * patients with a positive personal history of CRC Exclusion Criteria: * patients with personal history of CRC or inflammatory bowel disease * patients with a family history of hereditary conditions that put them at high risk for CRC (familial adenomatous polyposis or hereditary, nonpolyposis CRC) * inability to read and comprehend the Informed Consent or written survey * patients who are up-to-date with CRC screening guidelines based on their response to the baseline survey
References
Publications (5)
- BACKGROUNDLevy BT, Xu Y, Daly JM, Ely JW. A randomized controlled trial to improve colon cancer screening in rural family medicine: an Iowa Research Network (IRENE) study. J Am Board Fam Med. 2013 Sep-Oct;26(5):486-97. doi: 10.3122/jabfm.2013.05.130041. PMID 24004700
- BACKGROUNDDaly JM, Xu Y, Levy BT. Patients whose physicians recommend colonoscopy and those who follow through. J Prim Care Community Health. 2013 Apr 1;4(2):83-94. doi: 10.1177/2150131912464887. Epub 2012 Nov 4. PMID 23799714
- BACKGROUNDLevy BT, Daly JM, Xu Y, Ely JW. Mailed fecal immunochemical tests plus educational materials to improve colon cancer screening rates in Iowa Research Network (IRENE) practices. J Am Board Fam Med. 2012 Jan-Feb;25(1):73-82. doi: 10.3122/jabfm.2012.01.110055. PMID 22218627
- BACKGROUNDEly JW, Levy BT, Daly J, Xu Y. Patient Beliefs About Colon Cancer Screening. J Cancer Educ. 2016 Mar;31(1):39-46. doi: 10.1007/s13187-015-0792-5. PMID 25619196
- DERIVEDDaly JM, Xu Y, Ely JW, Levy BT. A randomized colorectal cancer screening intervention trial in the Iowa Research Network (IRENE): study recruitment methods and baseline results. J Am Board Fam Med. 2012 Jan-Feb;25(1):63-72. doi: 10.3122/jabfm.2012.01.110054. PMID 22218626