A Study of Home Administration of Pemetrexed as Maintenance Treatment for Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

* Have a histological or cytological diagnosis of NSCLC defined as nonsquamous cell histology. Squamous cell and/or small cell histology is not permitted. Mixed NSCLC tumors will be categorized by the predominant cell type. NSCLC tumors that are not otherwise specified with regard to histology or cannot be subclassified as squamous, adenocarcinoma, or large cell histology will be categorized as nonsquamous
* Have Stage IIIB (not amenable to curative treatment) or Stage IV NSCLC prior to induction therapy as defined by the American Joint Committee on Cancer (AJCC) Staging Criteria for Lung Cancer
* Have completed 4 induction cycles of platinum-based doublet therapy (type at the discretion of the physician) for treatment of their advanced disease.
* Have not progressed after 4 cycles of induction therapy. Documented radiographic evidence of a tumor response must occur at the end of Cycle 4 of induction therapy within 3 weeks before receiving the first cycle of study drug \[see Response Evaluation Criteria in Solid Tumors (RECIST), version (v) 1.1\]
* Receive on-study treatment no earlier than 21 days and no later than 42 days from Cycle 4 Day 1 of induction therapy
* Have a Performance Status (PS) of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) scale
* Meet the following guidelines if the participant has received prior radiation therapy:

  * Previous radiation therapy is allowed to \<25% of the bone marrow, but should have been limited and must not have included whole pelvis radiation
  * Participants must have recovered from the toxic effects of the treatment prior to study enrollment (except for alopecia)
  * Participants who received palliative chest (in other words, thoracic skeleton including dorsal spine) or palliative extrathoracic radiotherapy to preexisting lesions are allowed to be enrolled in this trial
* Have adequate organ function, including:

  * Adequate bone marrow reserve: absolute neutrophil count (ANC) (segmented and bands) \>=1.5x109/Liter (L), platelets \>=100x109/L, and hemoglobin \>=9 grams per deciliter (g/dL)
  * Hepatic: bilirubin \<=1.5 x upper limit of normal (ULN) and alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) \<=3.0 x ULN (ALP, AST, and ALT \<=5.0 x ULN are acceptable if the liver has tumor involvement
  * Renal: calculated creatinine clearance (CrCl) \>=45 milliliters per minute (mL/min) based on the original weight-based Cockcroft and Gault formula
* Are willing to comply with the following contraceptive criteria:

  * Females must be surgically sterile, postmenopausal or must have a negative serum or urine pregnancy test within 7 days prior to the first dose of study drug
  * Males and females with reproductive potential: Must agree to use a reliable method of birth control during the study and for 6 months following the last dose of study drug
* Have an estimated life expectancy of at least 12 weeks
* Have given written informed consent/assent prior to any study-specific procedures
* Are willing to comply with home delivery administration and have family or close environment support willing to comply with home delivery administration

Exclusion Criteria:

* Are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational product or no approved use of a drug or device (other than pemetrexed used in this study), or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
* Have previously completed or withdrawn from this study
* Have a serious concomitant systemic disorder (for example, active infection including human immunodeficiency virus)
* Have a serious cardiac condition, such as myocardial infarction within 6 months, angina, or heart disease, as defined by the New York Heart Association Class III or IV
* Have symptomatic central nervous system (CNS) malignancy or metastasis (screening not required). Participants with treated CNS metastases are eligible for this study if they are not currently receiving corticosteroids and/or anticonvulsants for at least 1 week before starting study treatment and their disease is asymptomatic and radiographically stable
* Are receiving concurrent administration of any other antitumor therapy
* Have a second primary malignancy that in the judgment of the investigator and sponsor may affect the interpretation of results
* Are unable to interrupt aspirin or other nonsteroidal anti-inflammatory agents, other than aspirin dose ≤1.3 grams per day, for a 5-day period (8-day period for long-acting agents, such as piroxicam)
* Are unable or unwilling to take folic acid or vitamin B12 supplementation
* Are unable or unwilling to take corticosteroids
* Are pregnant or lactating
* Have received a recent (within 30 days of enrollment) or are receiving concurrent yellow fever vaccination